Research Journal of Cardiology1819-34042151-8297Science International10.3923/rjc.2015.12.19SalamMohamed A. MahranZakaria EmranTarek KhalikHammouda Abdul 1201581The MPO is often released from stimulated polymorphonuclear leukocytes at sites of inflammation and is involved in the generation of reactive oxygen and nitrogen species and tissue damage. Thus, it can play a role of inflammatory skin disease such as psoriasis and subsequent development of cardiovascular comorbidities associated with psoriasis. To examine the association between serum myeloperoxidase and cardiovascular risk factor in psoriatic children in Damietta governorate. Fifty psoriasis children and fifty, age and sex matched controls were recruited from Pediatric and Dermatology Clinics at Al-Azhar University Hospital (New Damietta), Egypt. All were submitted to full history taking, clinical examination and laboratory investigation with measurement of myeloperoxidase serum levels. Present study showed that, there was significant increase of traditional risk factors for cardiac disease in study group when compared to control group. In addition, MPO was significantly increased in psoriasis patients (pointing to possible role in pathogenesis of psoriasis). However, there was no significant correlation between MPO and risk factors of psoriasis. On the other hand, there was significant positive correlation between MPO and duration of disease at the first followed by severity of the disease. The MPO played a role in pathogenesis of psoriasis. But, MPO do not play a role in development of CVD in children with psoriasis.]]>Agner, K.,1941Pages: 62Pages: 62Andelid, K., B. Bake, S. Rak, A. Linden, A. Rosengren and A. Ekberg-Jansson,2007101888895Cao, L.Y., D.C. Soler, S.M. Debanne, I. Grozdev and M.E. Rodriguez et al.,2014+ CD68+ macrophages in skin lesions.]]>61627Castellani, L.W., J.J. Chang, X. Wang, A.J. Lusis and W.F. Reynolds,20064713661377Cavusoglu, E., C. Ruwende, C. Eng, V. Chopra and S. Yanamadala et al.,20079913641368Christophers, E.,200725529534Davies, M.J., C.L. Hawkins, D.I. Pattison and M.D. Rees,20081011991234De la Sierra, A. and M. Larrousse,201024373379Gelfand, J.M., A.L. Neimann, D.B. Shin, X. Wang, D.J. Margolis and A.B. Troxel,200629617351741Gottlieb, A.B. and F. Dann,20091221150.e11150.e9Hansson, M., I. Olsson and W.M. Nauseef,2006445214224Kimball, A.B. and Y. Wu,20094811471156Klebanoff, S.J.,200577598625Ndrepepa, G., S. Braun, J. Mehilli, N. Von Beckerath, A. Schomig and A. Kastrati,2008389096Prey, S., C. Paul, V. Bronsard, E. Puzenat and P.A. Gourraud et al.,2010242330Reynoso-von Drateln, C., E. Martinez-Abundis, B.R. Balcazar-Munoz, R. Bustos-Saldana and M. Gonzalez-Ortiz,200348882885Rocha-Pereira, P., A. Santos-Silva, I. Rebelo, A. Figueiredo, A. Quintanilha and F. Teixeira,20013033339Rudolph, T.K., V. Rudolph and S. Baldus,20085820823Sawicki, M., G. Sypniewska, M. Kozinski, M. Gruszka and M. Krintus et al.,201141667671Shiba, Y., T. Kinoshita, H. Chuman, Y. Taketani and E. Takeda et al.,20082116001609Simsek, H., M. Sahin, A. Akyol, S. Akdag, H.U. Ozkol, H.A. Gumrukcuoglu and Y. Gunes,20132013Tang, W.H.W., W. Tong, R.W. Troughton, M.G. Martin and K. Shrestha et al.,20074923642370Wang, Y., H. Gao, C.M. Loyd, W. Fu and D. Diaconu et al.,201213220672075Yap, Y.W., M. Whiteman and N.S. Cheung,200719219228Zhang, R., M.L. Brennan, X. Fu, R.J. Aviles and G.L. Pearce et al.,200128621362142Rhew, E.Y. and R. Ramsey-Goldman,20065101105