Research Journal of Botany1816-49192152-0461Science International10.3923/rjb.2015.98.103Haldina cordifolia (Roxb.) Bark by using in vivo Animal Model Studies]]>JakariaMd. ParvezMohammad ZamanRashaduz Arifujjaman HasanMd. Imran SayeedMohammed Abu AliMd. Hazrat 32015103The present study was to investigate the analgesic activity of the methanol extract of H. cordifolia bark by using in vivo animal model studies. The effect was studied using acetic acid-induced abdominal constriction test and formalin induced hind paw licking test in mice model. The results of the study showed that the extract exhibited significant analgesic effect. In acetic acid-induced writhing test, significant percentage of inhibition (78.48%) shows that at the dose of 400 mg kg1 and at the same dose in formalin induced hand paw licking model shows significant activity in early phase (22.03% of inhibition) where in late phase (19.88% of inhibition) comparable to standard drug diclofenac sodium. These findings suggested that H. cordifolia bark has got the potential as a candidate for future analgesic agent.]]>Agarwal, M., V.K. Srivastava, K.K. Saxena and A. Kumar,2006Beta vulgaris against CCl4-induced hepatic injury in rats.]]>779193Ahmad, M., H. Imran, Z. Yaqeen, Z. Rehman, A. Rahman, N. Fatima and T. Sohail,2011Salvadora persica.]]>24323330Alemy, S., M. Karami, E. Hossini, M.A. Ebrahimzadeh and N.S. Majd,2012Salvia limbata on withdrawal syndrome in mice.]]>163842Al-Sobarry, M., A. Alwashli, Y. Cherrah and K. Alaoui,2011Jatropha unicostata Balf, as endemic plant in Yemen.]]>2375381Bukhari, I.A.,2013Carthamus oxycantha.]]>64369375Chaudhary, P., B. Goel and A.K. Ghosh,2012Adina cordifolia (Roxb) leaves in alloxan induced diabetic rats.]]>2S1630S1632Dash, P.P., A.K. Chaturvedi, A. Mishra and D. Chaturvedi,2014Haldina cordifolia.]]>49599Dongmo, A.B., J.G. Beppe, N. Tsabang and A. Kamanyi,2006Terminalia superba (Engl. et diels combretaceae).]]>2171177Doshi, K.A., R. Acharya, B.R. Shankar and M.B. Nariya,2014Eranda (Ricinus communis Linn.) root.]]>84548Elumalai, A. and M.C. Eswariah,2012296105Fakruddin, M., K.S.B. Mannan, R.M. Mazumdar and H. Afroz,2012Clausena heptaphylla.]]>2012Hunskaar, S. and K. Hole,198730103114Iqbal, P.F., A.R. Bhat and A. Azam,2009Adina cordifolia and their new thiosemicarbazone derivatives.]]>4422522259Jain, A.P., R.S. Pawar and A. Singhai,2007109093Kaushik, V., V. Parcha and R.L. Khosa,2009Haldina cordifolia bark extracts.]]>20126130Kasinadhuni, V.R.R., G. Rajashekhar, R. Rajagopalan, V.M. Sharma and C.V. Krishna et al.,1999Haldinia cordifolia.]]>709395Kumbhare, M. and T. Sivakumar,2011Caesalpinia pulcherrima.]]>1180184Musa, A.M., A.B. Aliyu, A.H. Yaro, M.G. Magaji, H.S. Hassan and M.I. Abdullahi,2009Anisopus mannii (N.E.Br) (Asclepiadaceae) in rodents.]]>3374378Murray, C.W., F. Porreca and A. Cowan,198820175186Ozturk, N., K.H.C. Baser, S. Aydin, Y. Ozturk and I. Calis,2002Gentiana lutea ssp. symphyandra on the central nervous system in mice.]]>16627631Parekh, J., D. Jadeja and S. Chanda, 200529203210Rahman, A.U., H. Imran, S.I. Taqvi, T. Sohail, Z. Yaqeen, Z.U. Rehman and N. Fatima,2015Aegle marmelos L. as an anti-nociceptive agent in different painful conditions.]]>28515519Rao, Α.V. and D.M. Gurfinkel,200017211235Sangameswaran, B. and M.S. Saluja,2012Adina cordifolia against ehrlich ascites carcinoma (EAC) in mice.]]>5716Sabir, M. and M.K. Razdan,1970Adina cordifolia (Karam ki Gaach).]]>14209210Santos, A.R., V.C. Filho, R. Niero, A.M. Viana and F.N. Moreno et al.,1994Phyllanthus in mice.]]>46755759Sharma, A., B. Sangameswaran, V. Jain and M.S. Saluja,2012Adina cordifolia against ethanol induce hepatotoxicity in rats.]]>1279284Shibata, M., T. Ohkubo, H. Takahashi and R. Inoki,198938347352Tjolsen, A., O.G. Berge, S. Hunskaar, J.H. Rosland and K. Hole,199251517Yaqeen, Z., N.H. Naqvi, H. Imran, N. Fatima, T. Sohail, Z. Rehman and A. Rahman,2013P. domestica L.]]>269194Zaman, R., M. Parvez, M. Jakaria, M.A. Sayeed and M. Islam,2015In vitro clot lysis activity of different extracts of Mangifera sylvatica roxb. Leaves.]]>9135140