Pakistan Journal of Nutrition1680-51941994-7984Asian Network for Scientific Information10.3923/pjn.2016.180.186Grifola frondosa polysaccharide (GFP) on Peritoneal Macrophage Activities of the Long-Term Heavy Load Exercising Mouse]]>HuangJian ShiYali SunMinjun 22016152Long-term heavy-load exercise can decrease macrophage activity. In this study, we separated 50 Kunming (KM) mice into comparison groups to investigate the immune-regulatory effects of Grifola frondosa polysaccharide (GFP) on long-term heavy-load exercising mice. We evaluate NO content, macrophage survival and growth, intracellular GSH and macrophage phagocytosis 4 weeks after gavaging long-term heavy-load exercising mice with GFP. After exercise, NO content, macrophage survival and growth, phagocytic index significantly reduced in the mice not fed GFP. Both medium and high doses of GFP drastically increased NO, phagocytic index and decreased intracellular GSH. High doses of GFP also increased macrophage survival and growth. With this study, we demonstrate that four weeks of heavy-load exercise can weaken peritoneal macrophage activity. A supplement of GFP fed to these mice improved their peritoneal macrophage activity. The effect for the high-dose GFP treatment is especially significant.]]>Adachi, K., H. Nanba and H. Kuroda,1987Grofola frondosa (Maitake).]]>35262270Adachi, Y., M. Okazaki, N. Ohno and T. Yadomae,1994Grifola frondosa.]]>1715541560Adachi, Y., N. Ohno and T. Yadomae,1998Grifola frondosa.]]>21278283Ceddia, M.A. and J.A. Woods,19998722532258Ceddia, M.A., E.W. Voss Jr. and J.A. Woods,200088804810Ferrandez, M.D. and M. De la Fuente,19991664753Heath, G.W., E.S. Ford, T.E. Craven, C.A. Macera, K.L. Jackson and R.R. Pate,199123152157Heath, G.W., C.A. Macera and D.C. Nieman,199214353365Hohl, R., R.L.P. Ferraresso, R.B. De Oliveira, R. Lucco, R. Brenzikofer and D.V. De Macedo,20094111551163Jin, Q.G. and M.Y. Feng,2005253437Jia, L. and Q. Yuan,2007159295Kodama, N., N. Harada and H. Nanba,2002Grifola frondosa, induces Th-1 dominant responses in carcinoma-bearing BALB/c mice.]]>90357360Lin, H.Y., C.C. Huang and K.F. Chang,200966254259Lei, P., W.N. Chen, D.X. Chen, X.W. Han, D.D. Hou and H.Q. Guan,2011Grifola frondosa on peritoneal macrophages and spleen cells in mouse with spleen deficiency.]]>17205207Mackinnon, L.T. and S.L. Hooper,199628285290Murphy, E.A., J.M. Davis, A.S. Brown, M.D. Carmichael, N. Van Rooijen, A. Ghaffar and E.P. Mayer,2004287R1354R1358Nanba, H., A. Hamaguchi and H. Kuroda,1987Grifola frondosa (Maitake).]]>3511621168Nieman, D.C., L.M. Johanssen, J.W. Lee and K. Arabatzis,199030316328Nieman, D.C.,200032S406S411Nanba, H.,1995768243245Nanba, H. and K. Kub,19981998Okazaki, M., Y. Adachi, N. Ohno and T. Yadomae,1995in vitro.]]>1813201327Pedersen, B.K. and D.C. Nieman,199819204206Romao, P.R.T., S.G. Fonseca, J.S. Hothersall, A.A. Noronha-Dutra, S.H. Ferreira and F.Q. Cunha,1999118559566Shi, Y., D. Cai, X. Wang and X. Liu,201282383390Si, C.,2005Sorokin, S.P., R.F. Hoyt Jr., W.R. Reenstra and N.A.F. McNelly,199724893103Takizawa, F., S. Tsuji and S. Nagasawa,1996397269272Thornton, B.P., V. Vetvicka, M. Pitman, R.C. Goldman and G.D. Ross,199615612351246Xu, S. and R. Bian,20053rd Edn.,Xia, D.D., Z. Lin, R. Li and Y. He,198921533537Yao, Y. and B. Zhang,199413211214Zhu, X.L., A.F. Chen and Z.B. Lin,2007Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice.]]>111219226Zamora, R., K.E. Matthys and A.G. Herman,19973218796