Pakistan Journal of Nutrition1680-51941994-7984Asian Network for Scientific Information10.3923/pjn.2013.793.799karimiGolgis JamaluddinRosita ParvanehKolsoom 82013128Obesity is associated with the alteration of the gut microbiota. In order to
determine the effects of probiotics on body weight management and its related
biomarkers we performed a systematic review using clinical trial, interventional
and experimental studies. We performed a broad search with no date restriction.
Primary outcomes were included the parameters related to body weight management.
Secondary outcomes were inflammatory markers, lipid profile, blood glucose and
insulin level. A total of 12 animal studies were identified. Among these, six
studies reported the significant changes in body weight and all the studies
had documented significant improvements in at least one body weight related
parameter. However, inflammatory markers and lipid profile were significantly
improved in the animal model; changes in body weight and energy intake that
could be due to probiotics supplementation were controversial. Different strains
of gut microbiota have different effects on weight changes. Further studies
are needed to identify the role of gut microbiota on weight regulation of human.]]>Al‐Lahham, S.A., H. Roelofsen, F. Rezaee, D. Weening, A. Hoek, R. Vonk and K. Venema,201242357364An, H.M., S.Y. Park, D.K. Lee, J.R. Kim and M.K. Cha et al.,2011Bifidobacterium spp. in high fat diet-induced obese rats.]]>2011Andersson, U., C. Branning, S. Ahrne, G. Molin and J. Alenfall et al.,20101189196Backhed, F., J.K. Manchester, C.F Semenkovich and J.I. Gordon,2007104979984Brun, P., I. Castagliuolo, V.D. Leo, A. Buda, M. Pinzani, G. Palu and D. Martines,2007292G518G525Cani, P.D., A.M. Neyrinck, F. Fava, C. Knauf and R.G. Burcelin et al.,20075023742383Chen, J.J., R. Wang, X.F. Li and R.L. Wang,2011236823831Considine, R.V., M.K. Sinha, M.L. Heiman, A. Kriauciunas and T.W. Stephens et al.,1996334292295Ferron, F., R.V. Considine, R. Peino, I.G. Lado, C. Dieguez and F.F. Casanueva,199746289293Fleissner, C.K., N. Huebel, M.M. Abd El-Bary, G. Loh, S. Klaus and M. Blaut,2010104919929Friedman, J.M.,200260S1S14Fukuchi, S., K. Hamaguchi, M. Seike, K. Himeno, T. Sakata and H. Yoshimatsu,2004229486493Griffiths, E.A., L.C. Duffy, F.L. Schanbacher, H. Qiao and D. Dryja et al.,2004In vivo effects of bifidobacteria and lactoferrin on gut endotoxin concentration and mucosal immunity in Balb/c mice.]]>49579589Hamad, E.M., M. Sato, K. Uzu, T. Yoshida and S. Higashi et al.,2009Lactobacillus gasseri SBT2055 influences adipocyte size via inhibition of dietary fat absorption in Zucker rats.]]>101716724Usman, A.H.,1999Lactobacillus gasseri strains.]]>82243248Jequier, E.,2002967379388Jumpertz, R., D. Son Le, P.J. Turnbaugh, C. Trinidad, C. Bogardus, J.I. Gordon and J. Krakoff,2011945865Kang, J.H., S.I. Yun and H.O. Park,2010Lactobacillus gasseri BNR17 on body weight and adipose tissue mass in diet-induced overweight rats.]]>48712714Kang, J.H., S.I. Yun, M.H. Park, J.H. Park, S.Y. Jeong and H.O. Park,2013Lactobacillus gasseri BNR17 in high-sucrose diet-induced obese mice.]]>2013Lee, H.Y., J.H. Park, S.H. Seok, M.W. Baek and D.J. Kim et al.,2006Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice.]]>1761736744Ma, X., J. Hua and Z. Li,200849821830Mathur, S.K., P. Jain and P. Mathur,20112011Matsuzaki, T., R. Yamazaki, S. Hashimoto and T. Yokokura,1997Lactobacillus casei in a Non-Insulin-Dependent Diabetes Mellitus (NIDDM) model using KK-Ay mice.]]>44357365McNeil, N.I.,198439338342Million, M., E. Angelakis, M. Paul, F. Armougom, L. Leibovici and D. Raoult,2012Lactobacillus species on weight gain in humans and animals.]]>53100108Murphy, E.F., P.D. Cotter, S. Healy, T.M. Marques and O. O'Sullivan et al.,20105916351642Naito, E., Y. Yoshida, K. Makino, Y. Kounoshi, S. Kunihiro, R. Takahashi and F. Ishikawa,2011Lactobacillus casei strain Shirota on insulin resistance in diet-induced obesity mice.]]>110650657Park, Y.H., J.G. Kim, Y.W. Shin, H.S. Kim and Y.J. Kim et al.,. Whang,2008Lactobacillus acidophilus 43121 and a mixture of Lactobacillus casei and Bifidobacterium longum on the serum cholesterol level and fecal sterol excretion in hypercholesterolemia-induced pigs.]]>72595600Rao, D.R., C.B. Chawan and S.R. Pulusani,2006Thermophilus milk on plasma cholesterol levels and hepatic cholesterogenesis in rats.]]>4613391341Samuel, B.S., A. Shaito, T. Motoike, F.E. Rey and F. Backhed et al.,20081051676716772Sato, M., K. Uzu, T. Yoshida, E.M. Hamad and H. Kawakami et al.,2008Lactobacillus gasseri SBT2055 on adipocyte size in rats.]]>9910131017Schmid, C., D.L. Goede, R.S. Hauser and M. Brandle,2006136254254Semova, I., J.D. Carten, J. Stombaugh, L.C. Mackey, R. Knight, S.A. Farber and J.F. Rawls,201212277288Sousa, R., J. Halper, J. Zhang, S.J. Lewis and W.I.O. Li,2008Lactobacillus acidophilus supernatants on body weight and leptin expression in rats.]]>2008Suzuki, Y., H. Kaizu and Y. Yamauchi,199162565571Caplan, M.S., R. Miller-Catchpole, S. Kaup, T. Russell and M. Lickerman et al.,1999117577583Wang, Z.T., Y.M. Yao, G.X. Xiao and Z.Y. Sheng,20041016191624Xiao, J.Z., S. Kondo, N. Takahashi, K. Miyaji and K. Oshida et al.,2003Bifidobacterium longum on blood lipids in rats and healthy adult male volunteers.]]>8624522461Yadav, H., S. Jain and P.R. Sinha,2007Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats.]]>236268Yin, Y.N., Q.F. Yu, N. Fu, X.W. Liu and F.G. Lu,2010Bifidobacteria on obesity in high-fat diet induced rats.]]>1633943401Zarfeshani, A., H. Khaza'ai, R.M. Ali, Z. Hambali, K.W.J. Wahle and M.S.A. Mutalib,2011Lactobacillus casei on the production of pro-inflammatory markers in streptozotocin-induced diabetic rats.]]>3168174