Pakistan Journal of Nutrition1680-51941994-7984Asian Network for Scientific Information10.3923/pjn.2013.496.504NkechiOsuji Faustina ChineduOnyenekwe Charles OsitadinmaIfeanyichukwu Martins EbereAhaneku Joseph MichaelEzeani PriscillaEzeugwunne Ifeoma 52013125Severe Oxidative stress has been reported in Tuberculosis
infected individuals as a result of tissue inflammation, poor nutrition and
poor immunity and this stress becomes more severe in those co-infected with
HIV. Therefore the present study was designed to assess the antioxidant status
of HIV infected participants with or without tuberculosis co-infections and
in HIV seronegative participants infected with tuberculosis. 193 participants
were randomly recruited for the study and grouped into: (i) Symptomatic HIV
infected participants with tuberculosis co-infections (n = 67) (ii) symptomatic
HIV infected participants without tuberculosis (n = 45) (iii) HIV seronegative
participants with Tuberculosis (n = 52) and (IV) HIV seronegative control participants
without tuberculosis (n = 29). Blood samples collected from the participants
were used for HIV screening, CD4+T cell count, glutathione reductase activity,
glutathione peroxidase activity, Total Antioxidant Status and albumin estimations.
The results showed that glutathione reductase, glutathione peroxidase and Total
Antioxidant Status were significantly lowered in both HIV infected participants
with or without tuberculosis and HIV seronegative participants with tuberculosis
(P<0.01), compared (in each case) with HIV seronegative participants without
tuberculosis. The CD4+T cell count were significantly low in HIV infected participants
with tuberculosis co-infections and HIV infected group without tuberculosis
when compared with HIV seronegative participants with or without tuberculosis.
However the CD4+T cell count in HIV infected participants with tuberculosis
was not significantly different when compared with HIV infected participants
without tuberculosis. The serum albumin were lowered in HIV infected participants
with tuberculosis and tuberculosis infected participants (P<0.01 in each
case). Correlation studies amongst groups showed significant correlation between
CD4+T cell count and antioxidants in both HIV and tuberculosis co-infected participants
and in HIV infected participants without tuberculosis (P<0.01 in each case).
Serum albumin correlated positively with the antioxidants in both HIV infected
participants and those co-infected with tuberculosis. There was no significant
correlation between CD4+T cell count and the antioxidants in HIV seronegative
participants with or without tuberculosis. The study observed alterations in
the levels of glutathione reductase, glutathione peroxidase, total antioxidant
status and albumin in tuberculosis infected participants and in HIV infected
participants with and without tuberculosis. This could be as a result of greater
utilization of antioxidants subsequent to increased oxidative stress. These
findings also further support a link between oxidative stress, tuberculosis
and HIV infection.]]>Akpotuzor, J.O., A.E. Udoh and M.H. Etukudo,2007P. falciparum infection in University of Calabar Teaching Hospital (UCTH), Calabar.]]>6485489Audu, D., C. Onwujekwe, J. Onubogu, N. Adedoyin and A. Onyeyejepu et al.,200541013Aukrust, P., A.M. Svardal, F. Muller, B. Lunden, R.K. Berge,P.M. Ueland and S.S. Froland,199586258267Barber, D.L., K.D. Mayer-Barber, C.G. Feng, A.H. Sharpe and A. Sher,201118615981607Boom, W., R. Wallis and K. Chervenak,19915927372743Carole, L. and C. Sterrit,1994714Cole, C., Q. Jian, T. Kottke, R.M. Diaz and A. Ahmed et al.,20051110731081Famularo, G., C. De Simone and S. Marcellini,199748423429FitzGerald, J.M. and S. Houston,19911614751Israel, N. and M.A. Gougerot-Pocidalo,199753864870UNAIDS,20102010Jon, D., M. Adrian and P. Joseph,200642523528Kauri, K., J. Kisham, K. Gurdeep and S. Rajinderjit,200512839753975Matos, E.D. and A.C.M. Lemos,20061013601367Oguntibeju, O., A. Esterhuyse and E. Truter,20104185196Olawumi, H. and P. Olatunji,20067351355Onyenekwe, C.C., N. Ukibe, S.C. Meludu, M. Ifeanyi and M.O. Ezeani et al.,200845151156Schluger, N.W. and W.N. Rom,1998157679691Sharma, S., A. Mohan and T. Kadhiravan,2005121550567Sundaram, M., S. Saghayam, B. Priya, K.K. Venkatesh and P. Balakrishnan et al.,200812e61e66Sylvain, G., L. Tazi and A. Banuls,20072007pp: 1-30pp: 1-30Yamanaka, K., F.S. Nomura, T. Akashi and T. Usuri,200176363370Zhang, M., J. Gong, O.V. Iyer, B.E. Jones, R.L. Modlin and P.F. Barnes,19941424352442Wiid, I., T. Seaman, E.G. Hoal, A.J. Benade and P.D. van Helden,200456101106