Pakistan Journal of Nutrition1680-51941994-7984Asian Network for Scientific Information10.3923/pjn.2011.773.780EsmaeiliFarzaneh Moshtaghi-KashanianGhollam-Reza HassannejadMohammad 82011108Consumption of unsaturated fatty acids could affect the immune response to oxidative or bacterial challenge. To evaluate the protective effect of dietary oils on immune system, female rats were fed for 6 weeks either with 25 or 210 mg/kg of corn or olive oils, followed by acute lipopolysaccharide (100 and 200 μg/kg) challenge. The cytokines (IL-4, IL-10 and IFN-γ) productions were evaluated and the values were compared with the corresponding results obtained for the untreated rats. Following low dose of LPS challenge, production of IL-4 and IL-10 were higher among the animals consumed oils (p<0.05) while production of IFN-γ was lower following septic shock (p<0.05). These observations may suggest consumption of corn or olive oil could have protective effects by production of pro-inflammatory cytokines. Furthermore, use of unsaturated fatty acids presented in these oils might be useful therapies in acute or chronic inflammatory diseases.]]>Abbas, A.K., K.M. Murphy and A. Sher,1996383787793Lastra, C.A., M.D. Barranco, V. Motilva and J.M. Herrerias,20017933950Bazzoni, F., N. Tamassia, M. Rossato and M.A. Cassatella,20104023602368Bitler, C.M., T.M. Viale, B. Damaj and R. Crea, 200513514751479Boehm, U., T. Klamp, M. Groot and J.C. Howard,199715749795Calder, P.C.,199819244247Caramia, G.,200628923Carrick, J.B., R.G. Schnellmann and J.N. Moore, 19942421426Castro, A., V. Bemer, A. Nobrega, A. Coutinho and P. Truffa-Bachi, 199828488495Clouva-Molyvdas, P., M.D. Peck and J.W. Alexander, 199216343347De Lorgeril, M., P. Salen, F. Paillard, F. Laporte, F. Boucher and J. De Leiris, 200254503515De Pablo, M.A. and G.A.D. Cienfuegos, 2000783139De Pablo, M.A., M.A. Puertollano and G.A.D. Cienfuegos,20029945950Docke, W.D., F. Randow, U. Syrbe, D. Krausch and K. Asadullah, 19973678681Flora, G.J.S., Y.W. Lee, A. Nath, W. Maragos, B. Hennig and M. Toborek, 200227185Gawecka, A., J. Michalkiewicz, M.K. Kornacka, B. Luckiewicz and I. Kubiszewska, 200832448453Hall, J.A., R.J.V. Saun, S.J. Tornquist, J.L. Gradin, E.G. Pearson and R.C. Wander, 200418880886Hennig, B., G. Reiterer, M. Toborek, S.V. Matveev, A. Daugherty, E. Smart and L.W. Robertson, 20051138387Ilich, J.Z., S. Cvijetic, I.C. Baric, I. Cecic and M. Saric, 200960319332Kris-Etherton, P.M., 2007107209212Kuller, L.H., L.S. Kinzel, K.K. Pettee, A.M. Kriska and L.R. Simkin-Silverman et al., 200615962974Leite, M.S., P. Pacheco, R.N. Gomes, A.T. Guedes and H.C. Castro-Faria-Neto et al., 200523173178Lichtenstein, A.H., L.J. Appel, M. Brands, M. Carnethon and S. Daniels et al.,20061148296Liu, C.T., H.M. Su, C.K. Lii and L.Y. Sheen, 200975205210Lowry, S.F., 199312812351241Ly, L.H., R. Smith R.S. Chapkin and D.N. McMurray, 2005139202209Marquez-Martin, A., R.D.L. Puerta, A. Fernandez-Arche, V. Ruiz-Gutierrez and P. Yaqoob, 200636211217Massaro, M., G. Basta, G. Lazzerini, M.A. Carluccio and F. Bosetti et al.,200288335344Massaro, M., M.A. Carluccio, A. Paolicchi, F. Bosetti, G. Solaini and R. De-Caterina, 200267175181Mosmann, T.R. and S. Sad,199617138146Muraille, E. and O. Leo, 19984719Nakamura, T., 200817349351Njoku, D.B., 20106519531Parekh, N., Y. Lin, S. Marcella, A.K. Kant and G. Lu-Yao,20081724672472Puertollano, M.A., E. Puertollano, G.A. De-Cienfuegos and M.A. De-Pablo, 2007985458Puertollano, M.A., E. Puertollano, A. Ruiz-Bravo, M. Jimenez-Valera, M.A. De-Pablo and G.A. De-Cienfuegos,200482370376Rasheed, Z., N. Akhtar, A.N. Anbazhagan, S. Ramamurthy, M. Shukla and T.M. Haqqi,2009611Roebothan, B.V. and R.K. Chandra, 1996666670Sadeghi, S., F.A. Wallace and P.C. Calder,199996404410Takeda, M., M. Imaizumi, S. Sawano, Y. Manabe and T. Fushiki,200117117120Utsunomiya, T., S.R. Chavali, W.W. Zhong and R.A. Forse,19941214333339Wallace, F.A., E.A. Miles, C. Evans, T.E. Stock, P. Yaqoob and P.C. Calder,200169449457Yamada, P., M. Zarrouk, K. Kawasaki and H. Isoda,2008116279287Yaqoob, P. and P.C. Calder,19957548553Yaqoob, P., J.A. Knapper, D.H. Webb, C.M. Williams, E.A. Newsholme and P.C. Calder,199867129135