Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2022.885.891Etlingera rubroloba A.D. Poulsen]]>JabbarAsriullah SahidinIdin MonstaveviSyahrah AnnisaMalakaMuhammad HajrulMalikFadhliyah IlyasY. Muhammad1020222510Background and Objective:Etlingera rubroloba A.D. Poulsen (E. rubroloba) is a plant endemic to South-East Sulawesi which is used empirically by local people as a pain reliever for joints and to increase endurance after typhoid fever. This study aimed to determine the antioxidant and anti-inflammatory activity of the ethanol extract stem of E. rubroloba. Materials and Methods: The stem of the ethanol extract of E. rubroloba with evaluated for antioxidants using the FRAP method and anti-inflammatory activity with the parameter level of Tumor Necrosis Factor-Alpha (TNF-α) in vivo by using 6 groups of rats, namely the normal, the negative (Na-CMC 0.5%), the positive control (Diclofenac sodium) and the ethanol extract group at doses of 200, 300 and 400 mg kg1 b.wt. Results: The results of this study indicated that the antioxidant activity value of the IC50 ethanol extract was 12.720±0.12 μg mL1 and ascorbic acid (vitamin C) as a standard control was 3.14±0.12 μg mL1. The TNF- α normal group (7.83 pg mL1), negative control (250.92 pg mL1), positive control (123.66 pg mL1), treatment group dose 200 (192.20 pg mL1), 300 (97, 95 pg mL1) and 400 mg kg1 b.wt. (28.78 pg mL1). Conclusion: This study concluded that the ethanol extract of the stem of E. rubroloba has a very strong antioxidant activity and is an anti-inflammatory which is the best in reducing levels of TNF-α at a dose of 400 mg kg1 b.wt.]]>Dhingra, A.K., B. Chopra, J.S. Dua and D.N. Parsad,20177117126Supit, I.A., D.H.C. Pangemanan and S.R. Marunduh,20153640643Sari, T.M., O. Fera and Y.P. Yonedi,2021Passiflora lingularis f. lobalata).]]>6241253Fristiohady, A., B. Sadarun, W. Wahyuni, M.H. Malaka and F. Ahmad et al.,2020Aaptos sp. and its antioxidant properties and acute toxicity.]]>108189Sahidin, I., W. Wahyuni, M.H. Malaka, A. Jabbar, I. Imran and M.A. Manggau,2018Etlingera calophrys stems.]]>11238241Rahayu, M., S. Sunarti, D. Sulistiarini and S. Prawiroatmodjo,20067245250Chan, E.W.C., Y.Y. Lim, L.F. Wong, F.S. Lianto and S.K. Wong et al.,2008109477483Lachumy, S.J.T., S. Sasidharan, V. Sumathy and Z. Zuraini,2010Etlingera elatior (torch ginger) flowers.]]>3769774Jabbar, A., Wahyuni, M. 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