Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2021.99.111F. MahmoudKhaled HammoudaAmal Z. S. AliHatem A. AminAzza 12021241Background and Objective: Red onions are one of the most consumed vegetable crops in Egypt, their peel is rich in antioxidants that reduce the risk of diabetes and weight is lost. The study aimed to extract bioactive compounds present in Egyptian Red Onion Peels Waste (ROPE), increasing their efficiency and protecting them using nano-encapsulation as new emerging technology. Materials and Methods: Extraction of the bioactive compounds in the Egyptian red onion peels was carried out to study their antioxidant activity before and after nano-emulsions and micro-capsules, their physical and morphological characteristics with their different nano-forms and their application in sponge cake products. The biological evaluation was also studied using rats and statistical analysis. Results: The results showed that the ethanol extracts high content of bioactive compounds compared to water extract and that the use of nano-technique as a new emerging technology in form of nano-emulsion using sodium alginate with diameter size between 8.3-13.6 nm. Results also indicated that there was an improvement in the efficiency of antioxidant activity at high-temperature degrees during baking, with a melting point of up to 223.64°C, with an improvement in the blood sugar levels of diabetic rats and a significant decrease in body weight. Conclusion: Nano treatments had a protective effect on liver, safety towards kidneys, lowering blood sugar, improving the efficiency comparing to the other samples and were more acceptable to the consumer.]]>Akaranta, O. and A.A. Akaho,201316337343Gorinstein, S., H. Leontowicz, M. Leontowicz, J. Namiesnik and K. Najman et al.,20085644184426Akaranta, O. and T.O. Odozi,1986Allium cepa) tannin extract.]]>18299303Kahkonen, M.P., A.I. Hopia, H.J. Vuorela, J.P. Rauha, K. Pihlaja, T.S. Kujala and M. Heinonen,19994739543962Marrelli, M., V. Amodeo, G. Statti and F. Conforti,2019Allium cepa L.: Focus on potential benefits in the treatment of obesity and related comorbidities.]]>2019Lachman, J., M. Orsák and V. Pivec,2000Allium cepa L.).]]>26125134Ly, T.N., C. Hazama, M. Shimoyamada, H. Ando, K. Kato and R. Yamauchi,20055381838189Nuutila, A.M., R. Puupponen-Pimia, M. Aarni and K.M. Oksman-Caldentey,200381485493Lachman, J., D. Pronek, A. Hejtmankova, J. Dudjak, V. Pivec and K. Faitova,2003Allium cepa L.) varieties.]]>30142147Kim, S.J. and G.H. Kim,2006153943Harbone, J.B. and R. J. Grayer,19801980Pages: 621Pages: 621Slimestad, R., T. Fossen and I.M. Vagen,2007551006710080Rivas-Gonzalo, J.C.,20032003Pages: 383Pages: 383Harbourne, N., J.C. Jacquier, D.J. Morgan and J.G. Lyng,2008111204208Corrales, M., R. Lindauer, P. Butz and B. Tauscher,20082008Albu, S., E. Joyce, L. Paniwnyk, J.P. Lorimer and T.J. Mason,2004Rosmarinus officinalis for the food and pharmaceutical industry.]]>11261265Esmaeilzadeh, k., R. Mohsenzadeh and F.Z. Raftani,20142426435Dhanani, T., S. Shah, N.A. Gajbhiye and S. Kumar,2017Withania somnifera.]]>10S1193S1199Gazori, T., M.R. Khoshayand, E. Azizi, P. Yazdizade, A. Nomani and I. Haririan,2009in vitro characterization.]]>77599606Soobrattee, M.A., V.S. Neergheen, A. Luximon-Ramma, O.I. Aruoma and T. Bahorun,2005579200213Aryal, S., M.K. Baniya, K. Danekhu, P. Kunwar, R. Gurung and N. Koirala,20192019Chithiraikumar, S., S. Gandhimathi and M.A. Neelakantan,20171137569580Hazra, A., K. Alexander, D. Dollimore and A. Riga,200475317330Carneiro, H.C.F., R.V. Tonon, C.R.F. Grosso and M.D. Hubinger,2013115443451Hosseini, G.S.H., A.S.M. Seyedain and M. Kashaninejad,201825854860Fatin, F., J.S. Wafaa and F.A. Wedad,2015616421651Lawless, H.T. and H. Heymann,20132013Pages: 116-139Pages: 116-139Al-Okbi, S.Y., A.G. Abdel-Razek, S.E. Mohammed and M. El-Sayed Ottai,201717267277Baur, F.J. and L.G. Ensminger,197754171172Chapman, D.G., R. Castillo and J.A. Campbell,195937679686Reitman, S. and S. Frankel,1957285663Tobias, G.J., Jr.R.F. McLaughlin and Jr.J. Hopper,1962Endogenous creatinine clearance: A valuable clinical test of glomerular filtration and a prognostic guide in chronic renal disease.]]>266317323Duncan, D.B.,195511142Singh, B.N., B.R. Singh, R.L. Singh, D. Prakash and D.P. Sing et al.,2009Allium cepa) peel with potent antioxidant and antimutagenic activities.]]>4711611167Sagar, N.A., S. Pareek and G.A. Gonzalez-Aguilar,20205724232432Amarowicz, R., I. Estrella, T. Hernandez, S. Robredo, A. Troszyńska, A. Kosińska and R.B. Pegg,2010Lens culinaris).]]>121705711Hussain, A.I., S.A.S. Chatha, S. Noor, Z.A. Khan, M.U. Arshad, H.A. Rathore and M.Z.A. Sattar,2012Arachis hypogaea L.) hulls.]]>5890896Enas, A.M.K.,2004Punica granatum L.) peels in normal and alloxan diabetic rats.]]>169299Al-Okbi, S.Y., A.M. Hussein, H.F. Elbakry, K.A. Fouda, K.F. Mahmoud and M.E. Hassan,201821348358