Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2021.815.820Faroug MohamedMalaz AhmadAlbara Mohammed ElmahiOsman BabkerAsaad Ma Ali WaggiallahHisham 72021247Background and Objective: Coronavirus disease (COVID-19) has spread throughout the world. Several studies have indicated that ABO blood group polymorphism could be connected to COVID-19 vulnerability and clinical outcomes, nevertheless, the findings are debatable. The aim of this study was to determine the most blood groups susceptible for COVID-19 infection among Sudanese patients suffering from different chronic diseases. Materials and Methods: The research included 200 participants. A total of 100 samples were collected as a case study from patients who had been found to have COVID-19 and a total of 100 samples were collected as a control from non-COVID-19 patients. The data was then gathered using a formal interview questionnaire and analyzed using the Statistical Package for Social Sciences (SPSS). Results: A total of 200 individuals were involved 100 of them was Patients and 100 were control. 51.4% were female and 48.6% were male. Current study revealed statistically significant difference between cases and controls. Blood group distribution was O positive as 59 (42.1%) followed by A Positive as 36 (25.7%), B positive 16 (11.4%), AB was 9 (6.4%) and only one (0.7%) was AB negative. In this study, the most common of other disease of COVID-19 patients were Asthma (6%), stomach ulcer (1%), renal failure (10%), diabetes (12%), hypertension (24%), vein thrombosis (1%), thrombosis (1%), heart disease (2%) and sinusitis (1%). Conclusion: There is a relation between ABO blood grouping and COVID-19 virus infection. The blood group distribution was O positive at 59 (42.1%), A positive at 36 (25.7%), B positive at 16 (11.4%), AB positive at 9 (6.4%) and AB negative at one (0.7 %). Blood group AB is the least likely to be infected with the COVID-19 virus, although blood group O Positive is the most likely.]]>Zhong, B.L., W. Luo, H.M. Li, Q.Q. Zhang, X.G. Liu, W.T. Li and Y. Li,20201617451752WHO.,20202020Shi, W., J. Lv and L. Lin,20201463240Padhi, S., S. Suvankar, D. Dash, V.K. Panda, A. Pati, J. Panigrahi and A.K. Panda,202027253258Zietz, M., J. Zucker and N.P. Tatonetti,20202020Walker, R.H, P.A. Hoppe and W.J. Judd,20052005Jing, W., S. Zhao, J. Liu and M. Liu,20202020Cheng, Y., G. Cheng, C.H. Chui, F.Y. Lau and P.K.S. Chan et al.,200529314471451Wang, D.S., D.L. Chen, C. Ren, Z.Q. Wang and M.Z. Qiu et al.,2012131461468Boren, T., P. Falk, K.A. Roth, G. Larson and S. Normark,1993Helicobacter pylori to human gastric epithelium mediated by blood group antigens.]]>26218921895Nordgren, J. and L. Svensson,20192019Flegel, W.A.,202010527062708Boudin, L., F. Janvier, O. Bylicki and F. Dutasta,202010528412843Ray, J.G., M.J. Schull, M.J. Vermeulen and A.L. Park,2021174308315Zeng, X., H. Fan, D. Lu, F. Huang and X. Meng et al.,20202020Zhao, J., Y. Yang, H. Huang, D. Li and D. Gu et al.,20202020Klok, F.A., M.J.H.A. Kruip, N.J.M. van der Meer, M.S. Arbous and D.A.M.P.J. Gommers et al.,2020191145147