Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2021.434.444Salvia officinalis Extract and 17β-Estradiol Suppresses Ovariectomy Induced Osteoporosis in Female Rats]]>Azmy Abd El-MotelpBosy Tarek EbrahimMarwa Khairy MohamedHanaa 32021243Background and Objective: Osteoporosis is a progressive metabolic disorder characterized by an impaired bone formation that leads to increased morbidity and mortality. Salvia officinalis is a source of phytoestrogens that could help mitigate the risk of osteoporotic rat fracture by exerting sex hormones. Therefore, the present study was designed to investigate the curative effect of Salvia officinalis Extract(SOE) and17β-estradiol (E2) and their combinationon bone loss in female rats with ovariectomy-induced estrogen deficiency Materials and Methods: Forty adult female albino rats were divided into five groups, which included Sham control (Sham), ovariectomy (OVX), OVX+SOE, OVX+E2 and OVX +SOE+E2.SOE (10 mL kg1) and E2 (30 μg kg1) had been daily gavaged in the OVX+SOE, OVX+E2 and OVX+SOE+E2, respectively for 6-weeks. Results: The model of ovariectomy resulted in osteoporosis as demonstrated by the decreased serum Ca, P, vitamin D, E2 level associated with a significant increase in PTH levels in comparison to the sham control group. Besides, OVX to rats caused up-regulation in the levels of CTX-1, P1NP, BALP, OC and RANKL comparable to the sham control group. 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