Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2020.1096.1102Celastrus hindsii Benth]]>Loan PhamThanh Huy NguyenVan Tam Tien HaThi Le Thu HoangThi NghiaPhanChi Quyen NguyenThi 82020238Background and Objective:Celastrus hindsii Benth. has been used for generations in Northern Vietnam, for the treatment of disease relating to ulcers, tumors and inflammation without safety evidence. This study's goal is to evaluate the safety of the aqueous extract of leaves of C. hindsii through an acute and semi-chronic toxicity oral administration. Materials and Methods: In the acute study, a single oral dose (1000, 3000, 5000 and 15000 mg kg1) of the aqueous of C. hindsii extract were administered to mice and observed for seven days. In the semi-chronic study, rabbits were administered daily with 1000 and 3000 mg kg1 of the extract for 35 days. Hematological and biochemical analyzes were carried out on blood and serum samples collected. Results: A single oral administration of 15000 mg kg1 per day for white mice did not determine the LD50 dose. At doses of 1000 and 3000 mg kg1 for 35 days, the extract from C. hindsii induced neither clinical symptoms of rabbits nor significant changes in hematological parameters such as; total blood cells, hemoglobin concentration, white blood cells and platelets. The quantity of aspartate transaminase (AST or GOT), alanine transaminase (ALT or GPT) of rabbits in the experimental and control group did not differ (p> 0.05). Liver and kidney organizations were also not affected adversely. Conclusion: The results indicate that the oral administration of C. hindsii extract did not produce any significant toxicity in mice, therefore, it is recommended to be used safely for traditional medical practices and modern pharmaceutical applications.]]>Ly, T.N., M. Shimoyamada and R. Yamauchi,2006Celastrus hindsii Benth leaves and their antioxidative activity.]]>5437863793Hu, X.Q., W. Han, Z.Z. Han, Q.X. Liu, X.K. Xu, P. Fu and H.L. Li,2014Celastrus hindsii.]]>7169172Kuo, Y.H., C.F. Chen, L.M.Y. Kuo, M.L. King, C.F. Chen and K.H. Lee,1995Celastrus hindsii.]]>5817351738Kuo, Y.H., C.J. Chou, L.M.Y. Kuo, Y.Y. Hu, Y.C. Chen, C.F. Chen and K.H. Lee,1996Celastrus hindsii.]]>41549551Kuo, Y.H. and L.M.Y. Kuo,1997Celastrus hindsii.]]>4412751281Huang, H.C., C.C. Shen, C.F. Chen, Y.C. Wu and Y.H. Kuo,2000Celastrus hindsii Benth.]]>4810791080Hu, X.Q., W. Han, Z.Z. Han, Q.X. Liu, X.K. Xu, P. Fu and H.L. Li,2014Celastrus hindsii.]]>3714111415Ministry of Medicine,19961996Mann, Jr.D.E., 19655413941394Abraham, W.B.,1978Smith, K., 20012nd Edn.,Donkor, K., L.N.K. Okine, W.K.M. Abotsi and E. Woode, 2014Cassia sieberiana D.C. in rodents.]]>48489Muoi, L.D., C. van Minh, L.D. Cu, T.M. Hoi and L.M. Huong,2009(In Vietnamese)(In Vietnamese)Awounfack, C.F., S.B. Ateba, S. Zingue, O.R. Mouchili and D. Njamen,2016Myrianthus arboreus P. Beauv. (Cecropiaceae) in Wistar rats.]]>194169178Kifayatullah, M., M.S. Mustafa, P. Sengupta, M.M.R. Sarker, A. Das and S.K. Das,2015Pericampylus glaucus (Lam.) Merr. in BALB/c mice.]]>4309315Wintola, O.A. and A.J. Afolayan,2018Lauridia tetragona (LF) RH. archer leaf in wistar rats.]]>14239247Gurnani, C., V. Kumar, S. Mukhija, P. Narula and R. Bhola,2014Bryophyllum pinnatum (Lam.) Kurz by in vitro nodal culture.]]>524062411Chi, V.V.,2012Vol. 1,pp: 623-625, (In Vietnamese)pp: 623-625, (In Vietnamese)Shapiro, J.M., H. Smith and F. Schaffner, 197920137140Viet, T.D., T.D. Xuan, T.M. Van, Y. Andriana, R. Rayee and H.D. Tran,2019Celastrus hindsii Leaves.]]>2019