Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2019.59.66Ali Elsidege AliLamyaa Mahdi HassanFathalrahman Eldin Gumaah ElzakiSalah 22019222Background and Objective: The fibrinogen receptor the human platelet antigen (HPA1 and HPA3) have an essential role in Atherothrombosis. This study aimed to detect the association of αIIbβ3 polymorphism with ischemic stroke in Sudanese patients and its association with the common risk factors. Methodology: This is a case-control study. Fifty atherosclerotic with ischemic stroke Sudanese patients were included in present study and were compared to apparently 50 healthy Sudanese subjects at the same ages. The ages of both groups were >18 years. About 5 mL of venous blood sample was taken from each patient and control. The laboratory analyses were done for HbA1c, lipid profile and DNA genotyping by polymerase chain reaction (PCR) followed by FokI and ScrFI digestion. Results: The result showed that, the risk factors (TRI.G, HDL, HbA1C, and body mass index were associated with the increased risk of ischemic stroke). None of the cholesterol levels and LDL increased the risk of stroke. The risk of ischemic stroke was higher with B/B genotype in HPA3 (p-value 0.009) and A/B genotype in HPA1 (p-value 0.041) and HPA1 (p-value 0.041). Conclusion: The αIIbβ3 polymorphism were with ischemic stroke in Sudanese patients.]]>Lozano, R., M. Naghavi, K. Foreman, S. Lim and K. Shibuya et al.,201238020952128Murray, C.J.L., T. Vos, R. Lozano, M. Naghavi and A.D. Flaxman et al.,201338021972223Liu, M., B. Wu, W.Z. Wang, L.M. Lee, S.H. Zhang and L.Z. Kong,20076456464Meschia, J.F., B.B. Worrall and S.S. Rich,20117369378Mendis, S., P. Puska and B. Norrving,20111st Edn.,pp: 3-18pp: 3-18Mehta, P.K., J. Wei and N.K. Wenger,201525140151Rao, H., J. Zhao, Z. Li, C. Huang and J. Qiao,20169275281Andrews, R.K., E.E. Gardiner, Y. Shen, J.C. Whisstock and M.C. Berndt,20033511701174Andrews, R.K. and M.C. Berndt,2004114447453Duan, H., Y. Cai and X. Sun,201218CR19CR24Karassa, F.B., M. Bijl, K.A. Davies, C.G. Kallenberg and M.A. Khamashta et al.,20034819301938Ribatti, D. and E. Crivellato,20073113391341Meisel, C., J.A. Lopez and K. Stangl,20043693854Goldschmidt-Clermont, P.J., L.D. Coleman, Y.M. Pham, G.E. Cooke and W.S. Shear et al.,1999A2 polymorphism in siblings of patients with premature coronary heart disease.]]>12312231229Bennett, J.S.,2005IIbβ 3.]]>11533633369Rivera, J., M.L. Lozano, L. Navarro-Nunez and V. Vicente,200994700711Weiss, E.J., P.F. Bray, M. Tayback, S.P. Schulman and T.S. Kickler et al.,199633410901094Carter, A.M., A.J. Catto, J.M. Bamford and P.J. Grant,19993026062611Nurden, A.T.,199574345351Reiner, A.P., S.M. Schwartz, P.N. Kumar, F.R. Rosendaal and R.M. Pearce et al.,2001112632636Saidi, S., T. Mahjoub, L.B. Slamia, S.B. Ammou, A.M. Al-Subaie and W.Y. Almawi,2008258186Unkelbach, K., R. Kalb, S. Santoso, H. Kroll, C. Mueller‐Eckhardt and V. Kiefel,199589169176Wang, X., J. Zhang, Y. Liu and Y. Zhang,201125287291Hagous, S.A. and I.K. Ibrahim,201631822Pongracz, E., A. Tordai, M. Csornai and Z. Nagy,2001142781785Rothwell, P.M., S.C. Howard, D.A. Power, S.A. Gutnikov and A. Algra et al.,20043523002305Ridker, P.M., C.H. Hennekens, C. Schmitz, M.J. Stampfer and K. Lindpaintner,1997A1/A2 polymorphism of platelet glycoprotein IIIa and risks of myocardial infarction, stroke and venous thrombosis.]]>349385388Carlsson, L.E., A. Greinacher, C. Spitzer, R. Walther and C. Kessler,19972813921395Meiklejohn, D.J., M.A. Vickers, E.R. Morrison, R. Dijkhuisen, I. Moore, S.J. Urbaniak and M. Greaves,2001In vivo platelet activation in atherothrombotic stroke is not determined by polymorphisms of human platelet glycoprotein IIIa or Ib.]]>112621631