Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2017.28.35Artocarpus altilis Leaves and GABA]]>IndrowatiMeti PratiwiRarastoeti Rumiyati AstutiPudji 12017201Background and Objective: Information about the Artocarpus altilis leaf as an antidiabetic associated with the active compounds Gamma Amino Butyric Acid (GABA) is still limited. This study was conducted to determine the effects of ethanolic extract of A. altilis leaves decoction and GABA on blood glucose levels and insulin expression of beta-cells in streptozotocin-induced diabetic rats. Material and Methods: This study was done by using completely randomized design and male Sprague Dewley rats. The rats were devided into normal control group and diabetic rats groups. Levels of bood glucose were measured using strip rapid test. The insulin expression in beta-cells was assessed using immunohistochemistry. Quantitative data were analyzed using ANOVA at 5% confidence level. Results: The result indicated that 50 mg k1 b.wt., GABA, 400 and 800 mg k1 b.wt., ethanolic extract of A. altilis leaves decreased the level of blood glucose and increased the insulin expression in pancreas beta-cells. Conclusion: The GABA and ethanolic extract of A. altilis leaves with a minimum dose of 400 mg k1 b.wt., can be used as an antidiabetic. Pancreas is the target organ was affected by GABA and A. altilis leaves as antidiabetic agents. Results of this study may support the development of research on the potency of GABA in natural materials as antidiabetic particularly type 1 diabetes.]]>Are, P.C., R.R.R. Adidala and G. Puchchakayala,2011Glochidion velutinum on streptozotocin-nicotinamide induced type 2 diabetic rats.]]>3126130Kante, K. and C.S. Reddy,2013Dolichos lablab (seeds) in streptozotocin-nicotinamide induced diabetic rats.]]>53240Baekkeskov, S., J. Kanaani, J.C. Jaume and S. Kash,200015279286Soltani, N., H. Qiu, M. Aleksic, Y. Glinka and F. Zhao et al.,20111081169211697ADA.,201437S1S2Lebovitz, H.E.,20117408419Lotulung, P.D.N., T. Mozef, C. Risdian and A. Darmawan,2014In vitro antidiabetic activities of extract and isolated flavonoid compounds from Artocarpus altilis (Parkinson) Fosberg.]]>14711Rajendran, R.,1992Artocarpus altilis (Parkinson) fosberg.]]>28386Indrowati, M., Suharno and C.J. Sugiharjo,2006Rattus norvegicus L.) yang dibebani glukosa setelah perlakuan ekstrak daun (Artocarpus altilis) park dan GABA gamma amino butyric acid.]]>19345359Indrowati, M. and J. Ariyanto,2012Artocarpus altilis Park) leaf extract].]]>9655660, (In Indonesian)Ragone, D.,1997Artocarpus altilis (Parkinson) Fosberg-Promoting the conservation and use of underutilized and neglected crops.]]>1997Mcintosh, C. and P. Manchew,1993656Roberts, M.R.,20072408409Kook, M.C. and S.C. Cho,201333377389Luscher, B. and C.A. Keller,2004A receptor trafficking, channel activity and functional plasticity of inhibitory synapses.]]>102195221Kittler, J.T. and S.J. Moss,2003A receptor activity by phosphorylation and receptor trafficking: Implications for the efficacy of synaptic inhibition.]]>13341347Gottlieb, D.I.,19882588289Zimmermann, H.,1993Pages: 144Pages: 144Adeghate, E. and A.S. Ponery,20023416Franklin, I.K. and C.B. Wollheim,2004123185190Sorenson, R.L., D.G. Garry and T.C. Brelje,19914013651374Taneera, J., Z. Jin, Y. Jin, S.J. Muhammed and E. Zhang et al.,20125519851994Wang, Q., X. Liang and S. Wang,20132013Jester, P.,20122012Cemek, M., S. Kaga, N. Simsek, M.E. Buyukokuroglu and M. Konuk,2008Matricaria chamomilla L. in streptozotocin-induced diabetic rats.]]>62284293El Hilaly, J., Z.H. Israili and B. Lyoussi,2004Ajuga iva in experimental animals.]]>914350Kohn, D.F. and C.B. Clifford,1984Nugroho, A.E.,20067378382, (In Indonesian)Wang, Z. and H. Gleichmann,1998475056Dong, H., M. Kumar, Y. Zhang, A. Gyulkhandanyan and Y.Y. Xiang et al.,200649697705Bansal, P., S. Wang, S. Liu, Y.Y. Xiang, W.Y. Lu and Q. Wang,20112011Bailey, S.J., M.A. Ravier and G.A. Rutter,2007A) receptor expression in mouse pancreatic islet α-cells.]]>56320327Quesada, I., E. Tuduri, C. Ripoll and A. Nadal,2008199519Braun, M., A. Wendt, B. Birnir, J. Broman and L. Eliasson et al.,2004123191204Indrowati, M., P. Astuti, R. Pratiwi and R. Rumiyati,2015Artocarpus altilis park.]]>2595600Indrowati, M. and C.J. Soegihardjo,2005Arocarpus atilis Park).]]>26164Andrali, S.S., M.L. Sampley, N.L. Vanderford and S. Ozcan,2008415110Garry, D.J., R.L. Sorenson, R.P. Elde, B.E. Maley and A. Madsen,19863510901095