Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2016.211.218Antidesma bunius (L.) Spreng in Streptozotocin-induced Diabetic
Rats]]>ChowtivannakulPichaya SrichaikulBuavaroon TalubmookChusri 52016195Background:Antidesma bunius (L.) Spreng has been reported to possess various beneficial medicinal properties. Scientific information
about this plant is limited. This study was therefore, designed to determine hypoglycaemic and hypolipidemic effects of ethanol seed
extract from A. bunius (ABSE). Antioxidant activity and also acute toxicity were conducted. Methodology: The hypoglycaemic and
hypolipidemic effects were studied by oral giving ABSE at a dose of 250 mg kg1 to streptozotocin-induced diabetic rats daily for 6 weeks.
Antioxidant activity was studied using DPPH assay. The ABSE at the doses of 500, 1000, 1500 and 2000 mg kg1 were employed in the
acute toxicity study. Results: The results revealed that ABSE significantly (p<0.05) reduced the blood glucose level and recovered the
pathology of hematological values, but significantly (p<0.05) increased the body weight and slightly increased serum insulin of the
diabetic rats. However, ABSE recovered pathology of hematological values, but affected renal and hepatic functions in the treated
rats by producing an alteration of creatinine, albumin, total protein, BUN and ALP. Interestingly, ABSE increased WBC and HDL, but
reduced CHOL, LDL and TG both in normal and diabetic ABSE treated rats. The ABSE possessed relatively low antioxidant activity with IC50
of 2174±14.24 mg mL1 compared to vitamin C (1.48±0.07 μg mL1). Fortunately, ABSE did not produce any symptoms of acute toxicity
and mortality in the rats. Conclusion: The ethanol seed extract from A. bunius possesses hypoglycemic and hypolipidemic effects. The
ABSE also recovered the pathology of the hematology but may cause renal dysfunction in the diabetic rats. The hypoglycemic and
hypolipidemic effects are likely due to its antioxidant and insulin secretion activities.]]>Talubmook, C.,2008Phellinus ignarius (L.) Quel. on hematological values and blood cell characteristics in diabetic rats.]]>224245Dean, R.T., S. Fu, R. Stocker and M.J. Davies,1997324118Valko, M., D. Leibfritz, J. Moncol, M.T.D. Cronin, M. Mazur and J. Telser,2007394484Wu, J.W., C.L. Hsieh, H.Y. Wang and H.Y. Chen,2009Psidium guajava L.) leaf extracts and its active compounds on the glycation process of protein.]]>1137884Kaneto, H., N. Katakami, M. Matsuhisa and T.A. Matsuoka,20102010Deetae, P., P. Parichanon, P. Trakunleewatthana, C. Chanseetis and S. Lertsiri,2012133953959Matough, F.A., S.B. Budin, Z.A. Hamid, N. Alwahaibi and J. Mohamed,201212518Xi, M., C. Hai, H. Tang, M. Chen, K. Fang and X. Liang,200822228237Rodrigues, E., N. Poerner, I.I. Rockenbach, L.V. Gonzaga, C.R. Mendes and R. Fett,201131911917Bocco, A., M.E. Cuvelier, H. Richard and C. Berset,19984621232129Cordenunsi, B.R., J.R.O. de Nascimento, M.I. Genovese and F.M. Lajolo,20025025812586Primetta, A.K., L. Jaakola, F.A. Ayaz, H. Inceer and K.R. Riihinen,2013Vaccinium myrtillus L.).]]>30662667Kahkonen, M.P., A.I. Hopia, H.J. Vuorela, J.P. Rauha, K. Pihlaja, T.S. Kujala and M. Heinonen,19994739543962Belina-Aldemita, M.D., V.C. Sabularse, E.I. Dizon, W.A. Hurtada and M.A.O. Torio,2013Antidesma bunius (L.) Spreng.] wine at different stages of processing.]]>96308313Lim, T.K.,2012Fragaria x ananassa.]]>2012pp: 395-409pp: 395-409Butkhup, L. and S. Samappito,200881534Koponen, J.M., A.M. Happonen, P.H. Mattila and A.R. Torronen,20075516121619Nohynek, L.J., H.L. Alakomi, M.P. Kahkonen, M. Heinonen, I.M. Helander, K.M. Oksman-Caldentey and R.H. Puupponen-Pimia,2006541832Seeram, N.P.,200856630635Lawag, I.L., A.M. Aguinaldo, S. Naheed and M. Mosihuzzaman,2012144217219Ojewole, J.A.O.,2002Clausena anisata (Willd) Hook methanolic root extract in rats.]]>81231237Sharma, S.B., A. Nasir, K.M. Prabhu, P.S. Murthy and G. Dev,2003Eugenia jambolana in alloxan-induced diabetic rabbits.]]>85201206Tembhurne, S.V. and D.M. Sakarkar,2009Murraya koenigii (L) in alloxan induced diabetic mice.]]>115891593Sowmya, A. and T. Ananthi,2011Mimosa pudica Linn on butter induced hyperlipidemia in rats.]]>1123126Rajendran, R. and E. Krishnakumar,2010Mimosa pudica leaves.]]>2215221Pothitirat, W., M.T. Chomnawang, R. Supabphol and W. Gritsanapan,200980442447Suwannaphet, W., S. Adisakwattana and S. Yibchok-anun,2009Vitis vinifera) in high fructose-fed rats.]]>315356Chis, I.C., M.I. Ungureanu, A. Marton, R. Simedrea, A. Muresan, I.D. Postescu and N. Decea,20096200204Maiti, R., D. Jana, U.K. Das and D. Ghosh,2004Tamarindus indica in streptozotocin-induced diabetic rats.]]>928591Monago, C.C. and E.O. Alumanah,2005Abrus precatorius Linn seed in alloxan diabetic rabbit.]]>98588Karthikeyan, A., G. Siva, S.P. Sujitha, D.A.P. Rex and N. Chidambaranathan,2008Vernonia anthelminticum willd.]]>2209211Zarei, A., G. Vaezi, A.A. Malekirad and M. Abdollahi,2015Salvia hydrangea on hepatic and renal functions of streptozotocin-induced diabetic rats.]]>5138147Kumar, R., V. Arora, V. Ram, A. Bhandari and P. Vyas,201534550Sakuljaitrong, S., N. Buddhakala, S. Chomko and C. Talubmook,2013Nelumbo nucifera) on hypoglycemic and hypolipidemic in streptozotocin-induced diabetic rats.]]>414411446Klangkarn, K., W. Promprom and C. Talubmook,2015Sphagneticola trilobata (L.) pruski.]]>334047