Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2015.11.18OliveiraIvaldo Jesus Lima de de SouzaVictor Vasconcelos MottaVitor Da-SilvaSergio Leme 12015181Vitamin C (ascorbic acid) is a well-known antioxidant that
is involved in anxiety, stress, depression, fatigue and mood state in humans.
Studies have suggested that oxidative stress may trigger neuropsychological
disorders. Antioxidants may play an important therapeutic role in combating
the damage caused by oxidative stress in individuals that suffer from anxiety.
In this context, it was hypothesized that oral vitamin C supplementation would
reduce anxiety. However, few up to date studies have evaluated the consequences
of oral vitamin C supplementation on anxiety in humans. The present study examined
the effects of oral vitamin C supplements in 42 high school students, in a randomized,
double-blind, placebo-controlled trial. The students were given either vitamin
C (500 mg day-1) or placebo. Plasma concentrations of vitamin C and
blood pressure were measured before the intervention and then one day after
the intervention. Anxiety levels were evaluated for each student before and
after 14 days following supplementation with the Beck Anxiety Inventory. Results
showed that vitamin C reduced anxiety levels and led to higher plasma vitamin
C concentration compared to the placebo. The mean heart rates were also significantly
different between vitamin C group and placebo control group. Present study results
not only provide evidence that vitamin C plays an important therapeutic role
for anxiety but also point a possible use for antioxidants in the prevention
or reduction of anxiety. This suggests that a diet rich in vitamin C may be
an effective adjunct to medical and psychological treatment of anxiety and improve
academic performance.]]>Aburawi, S.M., F.A. Ghambirlou, A.A. Attumi, R.A. Altubuly and A.A. Kara,20142014Amr, M., A. El-Mogy, T. Shams, K. Vieira and S.E. Lakhan,20132013Aronen, E.T., V. Vuontela, M.R. Steenari, J. Salmi and S. Carlson,2005833342Aschbacher, K., A. O'Donovan, O.M. Wolkowitz, F.S. Dhabhar, Y. Su and E. Epel,20133816981708Bates, C.J., C.M. Walmsley, A. Prentice and S. Finch,199816925932Beck, A.T., N. Epstein, G. Brown and R.A. Steer,198856893897Beesdo, K., A. Bittner, D.S. Pine, M.B. Stein, M. Hofler, R. Lieb and H.U. Wittchen,200764903912Bessey, O.A.,19601960pp: 303pp: 303Binfare, R.W., A.O. Rosa, K.R. Lobato, A.R.S. Santos and A.L.S. Rodrigues,200933530540Bouayed, J., H. Rammal and R. Soulimani,200926367Brody, S., R. Preut, K. Schommer and T.H. Schurmeyer,2002159319324Bruno, R.M., E. Daghini, L. Ghiadoni, I. Sudano and I. Rugani et al.,201296302308Cassady, J.C. and R.E. Johnson,200227270295Chang, C.W., M.J. Chen, T.E. Wang, W.H. Chang, C.C. Lin and C.Y. Liu,20075212591261Cunha, J.A.,2001Duffy, A., J. Horrocks, S. Doucette, C. Keown-Stoneman, S. McCloskey and P. Grof,2013150363369Evans-Olders, R., S. Eintracht and L.J. Hoffer,20102610701074Garlipp-Picchi, M., R. Deminice, P.P. Ovidio and A.A. Jordao,201319394398Gautam, M., M. Agrawal, M. Gautam, P. Sharma, A.S. Gautam and S. Gautam,201254244247Grigor'ev, I.P. and A.A. Neokesariiskii,1986102288289, (In Russian)Guney, E., M.F. Ceylan, A. Tektas, M. Alisik and M. Ergin et al.,20141566266Halliwell, B.,20069716341658Hamer, M., C.J. Bates and G.D. Mishra,2011197278Hamzah, M.H.,20072007Hovatta, I., J. Juhila and J. Donner,201068261275Jorm, A.F., H. Christensen, K.M. Griffiths, R.A. Parslow, B. Rodgers and K.A. Blewitt,2004181S29S46Khassaf, M., A. McArdle, C. Esanu, A. Vasilaki and F. McArdle et al.,2003549645652Kinsman, R.A. and J. Hood,197124455464Kuloglu, M., M. Atmaca, E. Tezcan, O. Gecici, H. Tunckol and B. Ustundag,2002462732Kuloglu, M., M. Atmaca, E. Tezcan, B. Ustundag and S. Bulut,200246186189Li, Y.F., K.L. Jackson, J.E. Stern, B. Rabeler and K.P. Patel,2006291H2847H2856Maes, M., P. Galecki, Y.S. Chang and M. Berk,201135676692Marim, R.G., A.S. de Gusmao, R.E.P. Castanho, R. Deminice and A.L.S. Therezo et al.,2012Trypanosoma cruzi QM1 strain.]]>54319323Masood, A., A. Nadeem, S.J. Mustafa and J.M. O'Donnell,2008326369379Mathew, S.J., R.B. Price and D.S. Charney,20081488998Mazloom, Z., M. Ekramzadeh and N. Hejazi,20131615971600Mazzone, L., F. Ducci, M.C. Scoto, E. Passaniti, V.G. D'Arrigo and B. Vitiello,20072007McCord, J.M.,199326351357McCraty, R.,20072007Moretti, M., J. Budni, A.E. Freitas, P.B. Rosa and A.L.S. Rodrigues,2014481624Moretti, M., J. Budni, D.B. dos Santos, A. Antunes and J.F. Daufenbach et al.,2013496879Moretti, M., J. Budni, C.M. Ribeiro and A.L.S. Rodrigues,20126872127Moretti, M., A. Colla, G. de Oliveira Balen, D.B. dos Santos and J. Budni et al.,201246331340Moretti, M., A.E.D. Freitas, J. Budni, S.C.P. Fernandes, G.D.O. Balen and A.L.S. Rodrigues,2011225328333Naidu, A.K.,20032003Ness, A.R., D. Chee and P. Elliott,199711343350Ng, F., M. Berk, O. Dean and A.I. Bush,200811851876Rammal, H., J. Bouayed, C. Younos and R. Soulimani,2008589173175Ranjana, S.K., R. Negi, D. Pande, S. Khanna and H.D. Khanna,201283238Rebec, G.V. and R.C. Pierce, 199443537565Sena, J.D.W., P.A. Lowe and S.W. Lee,200740360376Sindhi, V., V. Gupta, K. Sharma, S. Bhatnagar, R. Kumari and N. Dhaka,20137828835Suh, S.Y., W.K. Bae, H.Y. Ahn, S.E. Choi, G.C. Jung and C.H. Yeom,20122012Vitasari, P., M.N.A. Wahab, T. Herawan, A. Othman and S.K. Sinnadurai,20111538263830Wang, Y., X.J. Liu, L. Robitaille, S. Eintracht, E. MacNamara and L.J. Hoffer,201398705711Weinberger, D.R.,200134412471249Wiglusz, Z., A. Nasal, B. Damasiewicz and A. Radwanska,1983+-K+-adenosine triphosphatase activity of the central nervous tissues.]]>36313321Zhang, M., L. Robitaille, S. Eintracht and L.J. Hoffer,201127530533