Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2014.978.990SarkakiA. FathimoghaddamH. MansouriS.M.T. KorraniM. Shahrani SakiG. FarboodY. 82014178Cerebral Hypoperfusion Ischemia (CHI) has important role in
neuronal damage and behavioral deficits, including memory and Long-term Potentiation
(LTP) impairment. Protective effects of Gallic Acid (GA) on memory, hippocampus
LTP and cell viability were examined in permanent bilateral common carotid artery
occlusion in rats. Animals were divided into 9 groups: Control (Cont); sham
operated (Sho); Cerebral Hypoperfusion Ischemia (CHI); CHI received normal saline
(CHI +Veh); CHI treated with different doses gallic acid (50, 100, 200 mg kg-1
for 5 days before and 5 days after CHI induction, orally); CHI treated with
phenytoin (50 mg kg-1, ip) (CHI+Phe); and sham operated received
100 mg kg-1, orally (Sho+GA100). CHI was induced by bilateral common
carotid artery occlusion (2VO). Behavioral, electrophysiological and histological
evaluations were performed. Data were analyzed by one-way and repeated measures
ANOVA followed by tukeys post-hoc
test. GA improved passive avoidance memory, hippocampal LTP and cell viability
in hippocampus and cortex of ischemic rats significantly (p<0.01). The results
suggest that gallic acid via its antioxidative and free radicals scavenging
properties attenuates CHI induced behavioral and electrophysiological deficits
and has significant protective effect on brain cell viability. Dose of 100 mg
kg-1 GA has affected the ischemic but not intact rats and its effect
was more potent significantly than phenytoin, a routine drug for ischemic subjects.]]>Cai, Q.Y., X.S. Chen, X.L. Zhan and Z.X. Yao,20114972226Cavaglia, M., S.M. Dombrowski, J. Drazba, A. Vasanji, P.M. Bokesch and D. Janigro,20019108193Cechetti, F., A.S. Pagnussat, P.V. Worm, V.R. Elsner and J. Ben et al.,201287109116Cechetti, F., P.V. Worm, G. Lovatel, F. Moyses, I.R. Siqueira and C.A. Netto,2012912936Cechetti, F., P.V. Worm, L.O. Pereira, I.R. Siqueira and C.A. Netto,20104311781183Choi, B.R., K.J. Kwon, S.H. Park, W.K. Jeon, S.H. Han, H.Y. Kim and J.S. Han,2011209299Choi, B.R., S.R. Lee, J.S. Han, S.K. Woo and K.M. Kim et al.,20114225952604Dahiya, K., K. Aggarwal, S. Seth, V. Singh and T.K. Sharma,201056187190Dardiotis, E., G. Giamouzis, D. Mastrogiannis, C. Vogiatzi, J. Skoularigis, F. Triposkiadis and G.M. Hadjigeorgiou,20122012Davalos, A., A. Shuaib and N.G. Wahlgren,2000928De La Torre, J.C. and G. Aliev,200525663672Ding, W., D. Qian, J. Duan, E. Shang, Y. Tang, Y. Qian and N. Luo,201237366372Dirnagl, U., C. Iadecola and M.A. Moskowitz,199922391397Ergun, E., G. Kurt, M. Tonge, H. Aytar, M. Tas, K. Baykaner and N. Ceviker,201121471476Farkas, E., P.G. Luiten and F. Bari,200754162180Feng, Z., Y. Lu, X. Wu, P. Zhao and J. Li et al.,2012144313321Fujioka, M., T. Nakano, K. Hayakawa, K. Irie and Y. Akitake et al.,20123311071115Garcia, J.H., S. Wagner, K.F. Liu and X.J. Hu,199526627634Gottlieb, M., Y. Wang and V.I. Teichberg,200387119126He, X.L., Y.H. Wang, M.G. Bi and G.H. Du,20126804148Horecky, J., A. Gvozdjakova, J. Kucharska, M.E. Obrenovich and H.H. Palacios et al.,20118868875Huang, L., Z. He, L. Guo and H. Wang,200828757768Hai, J., Y.F. Wu, Q. Lin, X.S. Huang and G.Y. Zhang,2013113313317Karson, A., T. Utkan, F. Balci, F. Aricioglu and N. Ates,20122012Kasparova, S., V. Brezova, M. Valko, J. Horecky and V. Mlynarik et al.,200546601611Kim, Y.J.,20073010521055Kratz, J.M., C.R. Andrighetti-Frohner, D.J. Kolling, P.C. Leal and C.C. Cirne-Santos et al.,2008103437442Kratz, J.M., C.R. Andrighetti-Frohner, P.C. Leal, R.J. Nunes and R.A. Yunes et al.,200831903907Liu, X., C. Hunter, H.R. Weiss and O.Z. Chi,201031699703Mansouri, M.T., Y. Farbood, M.J. Sameri, A. Sarkaki, B. Naghizadeh and M. Rafeirad,201313810281033Mariotti, V., E. Melissari, S. Amar, A. Conte, R.H. Belmaker, G. Agam and S. Pellegrini,2010235300310Marquez-Martin, A., F. Jimenez-Altayo, A.P. Dantas, L. Caracuel, A.M. Planas and E. Vila,2012112511518Nabavi, S.F., S. Habtemariam, M. Jafari, A. Sureda and S.M. Nabavi,2012897377Nazem, A., A.H. Jafarian, S.H. Sadraie, A. Gorji, H. Kheradmand, M. Radmard and H. Haghir,20122819311936Ozacmak, V.H., H. Sayan, A. Cetin and A. Akyildiz-Igdem,20073213141321Paxinos, G. and C. Watson,20066th Edn.,Qi, F.H., T.Z. Jing, Z.X. Wang and Y.G. Zhan,2009Acer ginnala Maxim: Isolation, identification and their yield of gallic acid.]]>4998104Lashgari, R., F. Motamedi, S.Z. Asl, S. Shahidi and A. Komaki,2006171324328Roohbakhsh, A., A.H. Moghaddam, R. Massoudi and M.R. Zarrindast,200734223229Rosenberg, G.A.,200940S20S23Saransaari, P. and S.S. Oja,201038739746Saulle, E., D. Centonze, A.B. Martin, R. Moratalla, G. Bernardi and P. Calabresi,20023329782984Shibata, M., R. Ohtani, M. Ihara and H. Tomimoto,20043525982603Shinno, K., L. Zhang, J.H. Eubanks, P.L. Carlen and M.C. Wallace,199717955966Silva-Adaya, D., V. Perez-De La Cruz, M.N. Herrera-Mundo, K. Mendoza-Macedo and J. Villeda-Hernandez et al.,2008105677689Squire, L.R. and S.M. Zola,19966546552Tohda, M., P. Suwanakitch, R. Jeenapongsa, H. Hayashi, H. Watanabe and K. Matsumoto,20042720212023Vicente, E., D. Degerone, L. Bohn, F. Scornavaca and A. Pimentel et al.,20091251204212Wu, H.Q., L. Xie, X.N. Jin, Q. Ge, H. Jin and G.Q. Liu,198924482486Xu, L., L.A. Voloboueva, Y. Ouyang, J.F. Emery and R.G. Giffard,200929365374Xu, X., Z. Li, Z. Yang and T. Zhang,2012206136143Xu, Y., S.M. Liachenko, P. Tang and P.H. Chan,20094025122518Yoon, H.J., K.W. Park, Y.J. Jeong and D.Y. Kang,201226656664Zhang, H.N., J. Wu, T. Jin, M. Chang and L. Sun,201334471477