Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2014.872.875PourhassanAbolfazl 62014176It has been suggested that host genetic diversity may be associated
with Hepatitis C (HC). However, available data are tremendously heterogeneous
due to the influence of ethnic and geographical differences. This study aimed
to investigate possible association between certain Human Leukocyte Antigen
(HLA) class-I alleles with HC in a group of Azeri patients for the first time
in the literature. In a case-control study, 50 patients with confirmed HC (cases)
and 50 healthy age- and sex-matched counterparts (controls) were evaluated in
Tabriz Sina and Imam Reza Hospitals in a 2-year period of time (2011-2013).
The investigated HLA alleles in the present study were: A2, A3,
B35, B38, BW4, CW4 and CW7.
The A2-positive cases were significantly more frequent in the case
than in the control group (58 vs. 32%, p = 0.01, Odds Ratio (OR) = 2.9). Similar
trend was documented for A3 (62 vs. 26%, p<0.001, OR = 4.6), B35
(24 vs. 2%, p = 0.001, OR = 15.5) and BW4 (78 vs. 46%, p = 0.001,
OR = 4.2). In contrast, the rate of B38-positive (34 vs. 8%, p =
0.001, OR = 0.2) and CW7-positive (38 vs. 14%, p = 0.01, OR = 0.3)
cases was significantly higher in the hepatitis-C-negative subjects. There was
no significant difference in terms of the rate of CW4-positivity
between the two groups (20% in the cases vs. 34% in the controls, p = 0.12,
OR = 0.5). This study showed that there are significant associations between
certain HLA-I alleles with hepatitis C in Azeri patients. While some alleles
make the host prone to the disease, others may have a protective role in this
regard.]]>Abo Elmagd, E.K., K.S. Abdel-Wahab, Z.E. Alrasheedy and A.S. Khalifa,20117100108Anis, S., R. Muzaffar, M.N. Zafar, E. Ahmed, K. Fatima, S.A.A. Naqvi and S.A.H. Rizvi,200757300305Barakat, A.F., A. Hegazy, R.E. Farag, A. Abdul Baky, L.F. Arafa and A. Farouk,20128288298Barth, H., T.J. Liang and T.F. Baumert,200644527535Bidgoli, S.A., M.D. Zaverhei, M. Mohagheghi, B. Yazdanmehr, I. Jahanzad, N.E. Daryani and F.A. Ardalan,200732532Chang, K.M.,2003789105De Almeida, B.S., G.M.F. Silva, P.M. da Silva, R.D.M. Perez, F.A.F. Figueiredo and L.C. Porto,201118692699Farag, R.E., M.M. Arafa, S. El-Etreby, N.S. Saudy and B.S. Eldeek et al.,2013166873Hejazi, M.S., R. Ghotaslou, M.F. Hagh and Y.M. Sadigh,20076302308Hemeida, A.A., M. Osman, M. El-Shahat, M.H. Hashem, A. Mahmoud and H. Dahi,201179199Hong, X., R.B. Yu, N.X. Sun, B. Wang, Y.C. Xu and G.L. Wu,20051173027307Kilic, I.H., M.M. Koruk, M. Ozaslan, I.D. Karagoz and Y. Zer et al.,20128519526Ksiaa, L., S. Ayed-Jendoubi, I. Sfar, Y. Gorgi, H.A. Najjar, T.B. Abdallah and K. Ayed,200720312319McKiernan, S.M., R. Hagan, M. Curry, G.S.A. McDonald and A. Kelly et al.,200440108114Paladino, N., A.C. Flores, C.Y. Marcos, H. Fainboim and G. Theiler et al.,200769109111Ray, J.G.,19801st Edn.,pp: 92-103pp: 92-103Sebastiani, G.D., F. Bellisai, C. Caudai, P. Rottoli and P.E. Valensin et al.,2005191722Sheehan, M.M., C.T. Doyle, M. Whelton and E. Kenny-Walsh,199730512517Sohail, M.N., F. Rasul, A. Karim, U. Kanwal and I.H. Attitalla,2011611251152Tripathy, A.S., U. Shankarkumar, M.S. Chadha, K. Ghosh and V.A. Arankalle,2009130550555Vejbaesya, S., S. Songsivilai, T. Tanwandee, S. Rachaibun, R. Chantangpol and T. Dharakul,200061348353Wang, J.H., X. Zheng, X. Ke, M.T. Dorak and J. Shen et al.,20092009Yoon, S.K., J.Y. Han, C.W. Pyo, J.M. Yang and J.W. Jang et al.,20052511221127Zeisel, M.B., H. Barth, C. Schuster and T.F. Baumert,20091432743285