Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2014.740.743DeviJamuna RajkumarJohanna 52014175Cardiovascular and related disorders are one of the most common
disease prevailing all over the world. Hyperlipidemic condition have been largely
considered in the treatment of cardiovascular diseases. The present study was
carried out to investigate the effect of Ambrex on hematological factors in
hyperlipidemic rats and untreated hyperlipidemic rats. In this study, eighteen
rats were randomly divided into three groups of six animals each The groups
received normal diet (Control Group A) high fat diet (HFD group B) and Ambrex
treatment (Group C). After the study period, White Blood Cell (WBC), Red Blood
Cell (RBC), hematocrit (HCT), Hemoglobin, platelet (PLT), lymphocytes, monocytes,
granulocytes, Mean Corpuscular Hemoglobin Concentration (MCHC), plateletcrit
(Pct), Mean Corpuscular Volume (MCV), Platelet Distribution Width (PDW), red
cell distribution-standard deviation (RDW-SD), red cell distribution-correlation
variance (RDW-CV), micro red blood cell (μRBC), macroRBC were measured
using digital cell counter (MS9-3s). Hyperlipidemia increases markedly the PLT
count. Administration of Ambrex appeared to significantly increase WBC, Lymphocytes,
granulocytes. However, erythrocyte indices does not show statistically significant
variations among the test groups and control groups. The findings demonstrated
that Ambrex does not cause any significant undesirable alterations in hematological
factors in male rats. Ambrex also enhances white blood cell concentration and
lymphocytes which probably stimulate the immune defense mechanism.]]>Abdulrahman, F.I., J.C. Akan, O.A. Sodipo and P.A. Onyeyilli,20106812Ajagbonna, O.P., K.I. Onifade and U. Suleiman,1999Calotropis procera.]]>13642Choi, J.W. and S.H. Pai,2004341117121Devi, R.S., S. Narayan, K.V. Mohan, K.E. Sabitha and C.S. Devi,20034112941299Farnsworth, N.R., O. Akerele, A.S. Bingel, D.D. Soejarto and Z. Guo,198563965981Zhao, H., Y. Wang, Y. Wu, X. Li and G. Yang et al.,200941745753Kashinath, K.T.,19901990Kesmarky, G., G. Feher, K. Koltai, B. Horvath and K. Toth,2006356773Kostis, J.B., D. Turkevich and J. Sharp,198453997999Kwaan, H.C.,1992413235Lee, C.Y., K.C. Kim, H.W. Park, J.H. Song and C.H. Lee,200467133138Jainu, M. and C.S. Devi,200448343347Michael, W.M. and R.D. Frederick,19961996Pages: 484-485Pages: 484-485Ofuya, Z.M. and O.O. Ebong,1996123236Zandecki, M., F. Genevieve, J. Gerard and A. Godon,2007292141