Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2014.451.461Pontibacter spp. and Bacillus megaterium as a Probiotic Enhances Immune Responses in Labeo rohita]]>SumathiC. DillibabuV. MadhuriDash-Koney PriyaD. Mohana NagalakshmiC. SekaranG. 42014174This study stresses the key role which can be played by Tannery Fleshing (TF) hydrolyzing probiotic Pontibacter spp. in aqua feed formulation and identifies the probiotic strains in the fish gut capable of enhancing the overall growth and immune responses. Probiotics included are Pontibacter species (Pb) and Bacillus megaterium (BM) wherein Lactobacillus (LB) served as control. Experimental diets includes tannery fleshing (TF1), TF+LB strain (TF2), TF+BM strain (TF3), TF+Pb strain (TF4), Fishmeal+BM(TF5 ), Fishmeal+Pb and Control fish meal based diet (TF6). Compared with control, total weight gain (TWG), Specific Growth Rate (SGR), Feed Conversion Ratio (FCR) and Protein Efficiency Ratio (PER) in fish fed with diets supplemented with probiotics were significantly increased (p<0.05). NBT, lysozyme activity, total protein and globulin content were highest in TF4 diet. After challenge with Aeromonas hydrophila, TF4 recorded highest survival and TF1 lowest survival in comparison with the control. Growth and related parameters reveals the effective utilization potential of tannery fleshing probiotic as a feed source. Comparative studies with standard fish meal diets reveals that the fish fed with Pontibacter sps and Bacillus megaterium included feeds enhanced both assimilating capacity and immunological responses in Labeo rohita.]]>AOAC.,200518th Edn.,Al-Hafedh, Y.S.,1999Oreochromis niloticus).]]>30385393Alexander, J.B. and G.A. Ingram,19922249279Farzanfar, A.,200648149158Amend, D.F.,19811981pp: 447-454pp: 447-454Bairagi, A., K.S. Ghosh, S.K. 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