Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2013.548.550GoforoushanFarideh AzimiHamideh GoldustMohamad 1120131611Acne treatment depends on whether patents have a mild, moderate, or severe type of acne. The aim of this study was to compare the using of Isotretinoin (Rokutan) with and without oral vitamin E in treating acne. This study was performed on 60 patients on 0.5 mg/kg/day isotretinoin treatment for 6 months. The first group received 800 IU day-1 Vit E during treatment and the second group recieved 800 Iu day-1 cod liver oil capsules. All patients were observed for the complications at 1th, 4th and 6th weeks during treatment. Cheilitis was the most common side effect among these patients (69%). Epistaxis was the second side effect in both groups (22%). Other side effects were xerosis, pruritus, epigastric pain and nail fragility. The frequency and the severity of complications were less common at 4th and 6th weeks of treatment. Isotretinoin is a useful and effective drug in treating severe and treatment-resistance acne lesions.]]>Alonso-de-Celada, R.M. and R. De-Lucas Laguna,201229662663Bergler-Czop, B. and L. Brzezinska-Wcislo,201231188194Cooper, A.J.,20034497105Erturan, I., M. Naziroglu and V.B. Akkaya,201230552557Gan, E.Y., W.P. Koh, A.Z. Jin, A.W.H. Tan, H.H. Tan and M.B.Y. Tang,20122012Landis, E.T., M.M. Levender, S.A. Davis, A.N. Feneran, K.R. Gerancher and S.R. Feldman,201223272277Mehra, T., C. Borelli, W. Burgdorf, M. Rocken and M. Schaller,201292247248Stein, R.H. and M. Lebwohl,200120184189Strauss, J.S., A.B. Gottlieb, T. Jones, J.Y. Koo, and J.J. Leyden et al.,200043777784Vender, R. and R. Vender,20122012