Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2013.2062.2065Piliostigma thonningii on Activities
of Alanine Aminotransferase and Aspartate Aminotransferase in Serum and Liver in Rattus novergicus]]>AwhinE. P. JerohE. AnigboroA.A. RachaelNwaoroko 1220131624The effect of chronic consumption of Piliostigma thonningii
on the activities of Aspartate Aminotransferases (AST) and Alanine Aminotransferases
(ALT) on serum and liver of Rattus novergicus was investigated in this
research. The aim of this study was to check the possible effect of chronic
consumption of Piliostigma thonningii on the activities of the liver
biomarkers (ALT and AST) in Rattus novergicus. The results from this
study revealed that the activities of aspartate aminotransferase (AST) in serum,
showed a significant increase (34.20±12.9*) at (p<0.05) upon chronic
consumption of ethanolic extract of P. thonningii when compared with
that of the control B (18.02±1.54). The result also showed that the liver
AST was significantly increased (32.75±5.89*) when compared to that of
the control B (17.01±1.81) at (p<0.05). The results from the study
also revealed that there was a significant increase in the activity of alanine
aminotransferase in the liver (17.01±5.86*) when compared with that of
the control B (5.1±1.11) at (p<0.05). There was a corresponding increase
in serum activity of the enzyme ALT (13.65±3.79*) when compared with
that of the control B (9.4±1.98) at (p<0.05). The results from this
research has shown that chronic consumption of P. thonningii may cause
liver injury thereby, increasing the liver enzyme activity (17.01±5.86*).
This was shown in the corresponding increase in the serum level. Excessive consumption
of the extract of P. thonningii has a toxicity potential on the liver
and possibly other organs and tissues.]]>Sato, A.,201227625637Busia, K.,200519919923Fakae, B.B., A.M. Cambell, J. Barrett, I.M. Scott, P.H. Teesdale-Spittle, E. Liebau and P.M. Brophy,200014630634Fausto, N. and J.S. Campbell,2003120117130Giboney, P.T.,20057111051110Ighodaro, O.M. and J.O. Omole, 2012Piliostigma thonningii species leaf extract on lipid profile in Wistar rats.]]>2012Ighodaro, O.M., S.O. Agunbiade, J.O Omole and O.A. Kuti,2012Piliostigma thonningii leaves (Nigerian Species).]]>6537543Igoli, J.O., O.G. Ogaji, T.A. Tor-Anyiin and N.P. Igoli,20052134152Jimoh, F.O. and A.T. Oladiji,2005Piliostigma thonningii seeds: Proximate analysis, mineral composition and phytochemical screening.]]>414391442Reitman, S. and S. Frankel,1957285659Togola, A., D. Diallo, S. Dembele, H. Barsett and B.S. Paulsen,20052005