Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2013.201.207DeyAbhijit DeyAmrita DeJitendra Nath 52013165Scorpion bite is considered as one of the common and dangerous phenomenon throughout the world. The clinical manifestations include pulmonary edema, myocardial damage, intracerebral haemorrhage, brachial plexopathy, renal failure etc. which sometimes leads to mortality. The common antivenin therapy includes anti-scorpion venom serum or prazosin. In the vast rural areas of the third world countries phytotherapy is considered as an alternative system of medicine and scorpion sting is treated with the help of medicinal botanicals. As the safety and efficacy are considered as important aspects of anti venin therapy, conventional treatment can be supported by the herbal remedy. The present review compiles a number of medicinal plants pharmacologically evaluated in vitro and/or in vivo for scorpion antivenin properties. Considering the aspects like cost effectiveness, availability, lesser side effects and development of drug resistance, plant based anti venin therapy may be considered as a possible remedy against scorpion envenomation.]]>Abroug, F., S. ElAtrous, S. Nouira, H. Haguiga, N. Touzi and S. Bouchoucha,1999354906909Afifi, F.U., S. Al-Khalil, M. Aqel, M.H. Al-Muhteseb, M. Jaghabir, M. Saket and A. Muheid,1990Eryngium creticum extract on scorpion venom in vitro.]]>294349Akbar, S.,2011Andrographis paniculata: A review of pharmacological activities and clinical effects.]]>166677Alam, M.I. and A. Gomes,2003Vitex negundo and Emblica officinalis) root extracts.]]>867580Alkofahi, A., A.J. Sallal, and A.M. Disi,1997Eryngium creticum on the haemolytic activities of snake and scorpion venoms.]]>11540542Bahloul, M., I. Chabchoub, A. Chaari, K. Chtara and H. Kallel et al.,20108310841092Barua, A.K., P.C. Maiti and S.K. Chakraborti,1961Barringtonia acutangula.]]>50937940Bawaskar, H.S. and P.H. Bawaskar,2007Mesobuthus tumulus (Indian red scorpion) envenoming at rural setting.]]>551421Bawaskar, H.S. and P.H. Bawaskar,2011Mesobuthus tumulus) sting: Randomised open label clinical trial.]]>2011Belghith, M., M. Boussarsar, H. Haguiga, L. Besbes and S. Elatrous et al.,1999375157Brahmane, R.I., S.S. Pathak, V.V. Wanmali, K.J. Salwe, S.J. Premendran, and B.B. Shinde,2011in vitro and in vivo red scorpion venom neutralization activity of Andrographis paniculata.]]>34448Brown, N. and J. Landon,20105514051407Calderon-Aranda, E.S., D. Hozbor and L.D. Possani,199331327337Chen, Y., L. Cao, M. Zhong, Y. Zhang and C. Han et al.,20122012Gupta, S.D., A. Debnath, A. Saha, B. Giri and G. Tripathi et al.,2007Heterometrus bengalensis Koch) venom induced antiproliferative and apoptogenic activity against human leukemic cell lines U937 and K562.]]>31817825Deshpande, S.B.,201056253254Dey, A. and J.N. De,20106433440Dey, A. and J.N. De,20111219227Dey, A. and J.N. De,20111189194Dey, A. and J.N. De,20116129140Dey, A. and J.N. De,20121436880Dey, A. and J.N. De,20129153174Dey, A. and J.N. De,201218152165Dey, A. and J.N. De,2012 3291298Dey, A. and J.N. De,20122012Dey, A. and J.N. De, 20123151159Dey, A. and J.N. De,201286279Dey, A., T. Das and S. Mukherjee,2011In vitro Antibacterial activity of n-hexane fraction of methanolic extract of Plumeria rubra L. (Apocynaceae) Stem Bark.]]>6135142Diaz, P., G. D'Suze, V. Salazar, C. Sevcik, J.D. Shannon, N.E. Sherman and J.W. Fox,2009Tityus discrepans scorpion venom. A fluorescent probe study of microbial membrane Na+ permeability changes.]]>54802817Dube, S., V.K.Sharma, T.N. Dubey, N.B. Gouda and V. Shrivastava,2011109194195El-Alfy, A.T., A.A.E. Ahmed, A.J. Fatani and F. Kader,2008Leiurus quinquestriatus envenomation in rats by red grape seeds proanthocyanidins.]]>51321333Fatani, A.J., A.L. Harvey, B.L. Furman and E.G. Rowan,2000Leiurus quinquestriatus in vivo and in vitro.]]>3817871801Fatani, A.J., H.A. Al-Zuhair, H.I. Yaquob, A.A. Abdel-Fattah, M.I. El-Sayed and F.A. El-Sayed,2006Ginkgo biloba extract and the protease inhibitor aprotinin against Leiurus quinquestriatus venom-induced tissue damage in rats.]]>12255275Girish, K.S. and K. Kemparaju,2005Naja naja venom Hyaluronidase by plant derived bioactive components and polysaccharides.]]>70948952Goncalves, E., B.T. Maia and H.M. Junior,20122012Gupta, B.D., M. Parakh and A. Purohit,201056115118Haldar, S., S. Das Gupta, A. Gomes, B. Giri and S.C. Dasgupta et al.,2010Heterometrus bengalensis C.L. Koch) venom having antiosteoporosis activity in female albino rats.]]>55455461Hussein, F.T. and N.A. El-Sebakhy,1974Aristolochia elegans.]]>25310314Hutt, M.J. and P.J. Houghton,19986097110Ismail, M.,199533825858Izquierdo, A.M., E.V. Zapata, J.E. Jimenez-Ferrer, C.B. Munoz, A.J. Aparicio, K.B. Torres and L.O. Torres,2010Aristolochia elegans.]]>48891896Jimenez-Arellanes, A., R. Leon-Diaz, M. Meckes, A. Tapia, G.M. Molina-Salinas, J. Luna-Herrera and L. Yepez-Mulia,2012Aristolochia elegans rhizomes.]]>2012Jimenez-Ferrer, E., I. Reynosa-Zapata, Y. Perez-Torres and J. Tortoriello,2005Centruroides limpidus limpidus on the pancreas of mice and the antagonistic action of the Bouvardia ternifolia extract.]]>126571Jimenez-Ferrer, J.E., Y.Y. Perez-Teran, R. Roman-Ramos and J. Tortoriello,200512116122Jolad, S.D., J.J. Hoffman, S.J. Torrance, R.M. Wiedhopf, J.R. Cole et al.,1977Bouvardia ternifolia (Rubiaceae).]]>9980408044Kari, R.K. and H. Zolfaghrian,1986Buthus tamulus) venom.]]>30215222Karnad, D.R.,200957299300Lans, C., T. Harper, K. Georges and E. Bridgewater,20012001Li, Q., Z. Zhao, D. Zhou, Y. Chen and W. Hong et al.,20113215181525Maheshwari, M. and C.P. Tanwar,2012131618Malhotra, K.K., C.M. Mirdehghan and H.D. Tandon,197827623626Mansour, N.M., M.N. Tawfik, A.E. Yaseen and T.R. Rahmy,2007Ambrosia maritima plant extract on hepatic tissues of rats envenomed with Leiurus quinquestriatus scorpion.]]>469100Mansour, N.M., M.N. Tawfik, T.R. Rahmy and A.E. Yaseen,2007Ambrosia maritima plant extract on renal tissues of rats envenomed with Leiurus quinquestriatus scorpion.]]>4101130Mansour, N.M., M.N. Tawfik, A.E. Yaseen and T.R. Rahmy,2011Ambrosia maritima plant extract against alterations induced by Leiurus quinquestriatus scorpion venom on skeletal muscles and intestinal tissues of rats.]]>881103Mills, C., A.R. Carroll and R.J. Quinn,2005Barringtonia acutangula.]]>68311318Mills, E.J. and N. Ford,20112011Mukherjee, S., A. Dey and T. Das,2012In vitro antibacterial activity of n-hexane fraction of methanolic extract of Alstonia scholaris L. R.Br. stem bark against some multidrug resistant human pathogenic bacteria.]]>2110Murthy, K.R.K. and M.A. Zare,1998Mesobuthus tamulus concanesis, Pocock) venom on thyroxine and triiodothyronine in experimental acute myocarditis and its reversal by species specific antivenom.]]>361621Naqvi, R., A. Naqvi, F. Akhtar and A. Rizvi,199882295295Natu, V.S., S.B. Kamerkar, K. Geeta, K. Vidya and V. Natu et al.,201056275280Nazimuddin, S.K., S. Ramaswamy and L. Kameswaran,1978Andrographis paniculata on snake venom induced death and its mechanism.]]>40132133Pal, B.C., T. Chaudhuri, K. Yoshikawa and S. Arihara,1994Barringtonia acutangula.]]>3513151318Samy, R.P., P. Gopalakrishnakone, M.M. Thwin, T.K.V. Chow, H. Bow, E.H. Yap and T.W.J. Thong,20072 enzymes.]]>102650659Prasad, R., O.P. Mishra, N. Pandey and T.B. Singh,201178544548Rubin, D.I. and M. Vavra,201144131135Shi, L.S., P.C. Kuo, Y.L. Tsai, A.G. Damu and T.S. Wu,2004Aristolochia elegans.]]>12439446Srinivasan, K.N., P.T. Gopalakrishnakone, K.C. Tan, B. Chew and R.M. Cheng et al.,2002402331Thirunavukkarasu, A.B. and V. Chandrasekaran,2011578384Tiwari, A.K. and S.B. Deshpande,1993Buthus tamulus) venom in mammals is influenced by the age and species.]]>3116191622Tuuri, R.E. and S. Reynolds,201127667672Uawonggul, N., A. Chaveerach, S. Thammasirirak, T. Arkaravichien, C. Chuachan and S. Daduang,2005Heterometrus laoticus scorpion venom activity on fibroblast cell lysis.]]> 103201207Venkateswarlu, Y., B. Janakiram and G.R. Reddy,1988In vitro., neutralization of the scorpion, Buthus tamulus venom toxicity.]]>32187194Wu, T.S., Y.L. Tsai, A.G. Damu, P.C. Kuo and P.L. Wu,2002Aristolochia elegans.]]>6515221525Wu, T.S., Y.L. Tsai, P.L. Wu, Y.L. Leu, F.W. Lin and J.K. Lin,2000Aristolochia elegans.]]>63692693Zhang, Y.Y., L.C. Wu, Z.P. Wang, Z.X. Wang, Q. Jia, G.S. Jiang and W.D. Zhang,2009in vitro.]]>12431