Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2009.353.359Brucella abortus Biotype 1 Infection on the Reproductive Performance of Sprague-Dawley Rats]]>Ariful IslamMd. Minara KhatunMst. Kirl BaekByeong Il LeeSung 42009124The aim of this study was to assess the impact of Brucella abortus biotype 1 infection on the reproductive performance using Sprague-Dawley (SD) rat model. Virgin female SD rats (n = 24) were infected intraperitoneally with 0.1 mL of saline containing 1x1011 Colony Forming Unit (CFU) of pathogenic B. abortus biotype 1 Korean bovine isolate. Control rats (n = 24) were inoculated with 0.1 mL of apyrogenic saline. Both inoculated and control rats were divided into six subgroups. Four rats in each subgroup were consistently bred at 3, 7, 14, 21, 28 and 60 days after infection. B. abortus infection induced 41.67% infertility in the infected rats. The mean number of offspring/litter was 8.71±2.01 for infected rats and 12.87±1.42 for control rats (p<0.001). The mean weight of the viable offspring was 6.10±0.36 g for infected rats and 7.15±0.40 g for control rats (p<0.001). The rate of stillbirth was 12.30% in the infected rats. B. abortus biotype 1 was isolated from the uteri of the infected rats. The data of this study indicate that B. abortus biotype 1 infections in SD rat model affect reproduction adversely by causing infertility, stillbirth and loss of number and weight of offspring.]]>Alton, G.G., L.M. Jones, R.D. Angus and J.M. Verger,19881st Edn.,Pages: 174Pages: 174Baek, B.K., B.O. Lee, J. Hur, M.S. Rahman, S.I. Lee and I. Kakoma,2005Brucella abortus.]]>69305308Bonnett, B.N., S.W. Martin and A.H. Meek,199315205220Bosseray, N.,1982Brucella abortus infection in mouse model.]]>13341349Boulouis, H.J., F. Barrat, D. Bermond, F. Bernex, D. Thibault, R. Heller, J.J. Fontaine, Y. Yves Piemont and B.B. Chomel,2001Bartonella birtlesii infection in experimentally infected mice and pathogenic effect on reproductive functions.]]>6953135317Bricker, B.J. and S.M. Halling,1994Brucella abortus bv. 1, 2 and 4, Brucella melitensis, Brucella ovis and Brucella suis bv. 1 by PCR.]]>3226602666Crawford, R.P., J.D. Iiubeb and B.S. Adams,19901990pp: 137-149pp: 137-149Deyoe, B.L.,19801980Enright, F.M.,1990Brucella Infection in Domestic Animals.]]>1990Givens, M.D.,200666648654Golding, B., D.E. Scott, O. Scharf, L.Y. Huang and Y. Zaitseva et al.,2001Brucella abortus.]]>34348Herath, S., H. Dobson, C.E. Bryant and I.M. Sheldon,2006691322Kirkbride, C.A.,199356468Krishnan, L., L.J. Guilbert, T.G. Wegmann, M. Belosevic and T.R. Mosmann,1996156653662Lamb, V.L., L.M. Jones, G.G. Schurig and D.T. Berman,1979Brucella abortus lipopolysaccharides.]]>26240247Lapaque, N., I. Moriyon, E. Moreno and J.P. Gorve,2005Brucella lipopolysaccharide acts as a virulent factor.]]>86066Lim, H.S., Y.S. Min and H.S. Lee,200538482488Macedo, G.C., D.M. Magnani, N.B. Carvalho, O.B. Romero, R.T. Gazzinelli and S.C. Oliveira,2008Brucella abortus infection.]]>18010801087Meador, V.P., W.A. Hagemoser and B.L. Deyoe,1988Brucella abortus infected pregnant goats.]]>49274280Pappas, G., N. Akritidis, M. Bosilkovski and E. Tsianos,200535223252336Pappas, G., P. Papadimitriou, N. Akritidis, L. Christou and E.V. Tsianos,200669199Park, M.Y., C.S. Lee, Y.S. Choi, S.J. Park, J.S. Lee and H.B. Lee,200520941946Radostits, O.M., C.C. Gay, K.W. Hinchcliff and P.D. Constable,200710th Edn.,Rhyan, J.C., W.J. Quinn, L.L. Stackhouse, J.J. Henderson, D.R. Ewalt, J.B. Payeur, M. Johnson and M. Meagher,1994Brucella abortus biovar 1 in a free-ranging bison (Bison bison) from Yellowstone National Park.]]>30445446Robison, C.D., D.S. Davis, J.W. Templeton, M. Westhusin, W.B. Foxworth, M.J. Gilsdorf and L.G. Adams,1998Brucella abortus.]]>34582589Royal, M.D., A.Q. Darwash, A.P.F. Flint, R. Webb, J.A. Woolliams and G.E. Lamming,200070487501Semambo, D.K., T.R. Ayliffe, J.S. Boyd and D.J. Taylor,19911291216Tobias, L., D.O. Cordes and G.G. Schurig,1993Brucella abortus strain 2308.]]>30119129Wee, S.H., N.M. Nam and C.H. Kim,2008162556557Whatmore, A.M., S.J. Shankster, L.L. Perrett, T.J. Murphy, S.D. Brew, R.E. Thirlwall, S.J. Cutler and A.P. MacMillan,20064419821993Yaeger, M. and L.D. Holler,19971997Young, E.J.,199521283289