Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2009.1548.1555ImamSafaa S.KandilManal E.ShomanM. BakerSalwa I.BahierR. 1220091224The aim of the study was to assess umbilical cord ghrelin
level in term and preterm newborns and its relation to other metabolic hormones
and anthropometric measurements. A cross sectional comparative study included
50 normal appropriate-for-gestational-age newborns (25 full-terms; 25 preterm).
Assessment of anthropometric measurements, cord levels of ghrelin, leptin, insulin
and glucose were done to all newborns. Umbilical cord ghrelin was detected in
all newborns. There was no significant difference between term and preterm groups
regarding ghrelin, insulin and glucose. Leptin was significantly lower in preterm
than term group. Sex and mode of delivery had no effects regarding all studied
variables. There was no overall correlation between ghrelin and gestational
age, anthropometric measurements, leptin, insulin or glucose in all newborns.
Preterm group demonstrated significant correlations between ghrelin and weight,
body mass index and abdominal circumference. An overall significant correlation
was found between leptin and gestational age and anthropometric measurements
in all newborns. In preterm group leptin correlated with weight, length, subscapular
skin-fold thickness and abdominal circumference. To conclude the umbilical cord
ghrelin was relatively invariable at birth between 30 and 41 weeks gestation
showing no gestational age-related variation, unlike leptin, which was lower
in preterm group indicating increased adipose mass and placental maturation
with increased gestational age.]]>Alexe, D., G. Syridou and E. Petridou,20064326335Amico, J.A., A. Thomas, R.S. Crowley and L.A. Burmeister,19986313871395Ballard, J.L., J.C. Khoury, K. Wedig, L. Wang, B.L. Eilers-Walsman and R. Lipp,1991119417423Bellone, S., A. Rapa, D. Vivenza, A. Vercellotti and A. Petri et al.,200326RC911Bellone, S., A. Rapa, D. Vivenza, A. Vercellotti and A. Petri et al.,200460613617Bellone, S., R. Baldelli, G. Radetti, A. Rapa and D. Vivenza et al.,20069110291933Bray, G.A. and D.A. York,19978227712776Broglio, F., E. Arva, A. Benso, C. Gottero and G. Muccioli et al.,20018650835086Chan, J.L., J. Bullen, J.H. Lee, N. Yiannakouris and C.S. Mantzoros,200489335343Chanoine, J.P., L.P. Yeung, A.C. Wong and C.L. Birmingham, 200235282286Chiesa, C., J.F. Osborn, C. Haass, F. Natale and M. Spinelli et al,200854550558Considine, R.V., M.K. Sinha, M.L. Heiman, A. Kriauciunas and T.W. Stephens et al.,1996334292295Cortelazzi, D., V. Cappiello, P.S. Morpurgo, S. Ronzoni and M.S. Nobile de Santis et al.,2003149111116Druce, M.R., A.M. Wren, A.J. Park, J.E. Milton and M. Patterson et al.,20052911301136Farquhar, J., M. Heiman, A.C.K. Wong, R. Wach, P. Chessex and J.P. Chanoine,20038843244327Flanagan, D.E., M.L. Evan, T.P. Monsod, F. Rife, R.A. Heptulla, W.V. Tamborlane and R.S. Sherwin,2003284E313E316Fuglsang, J., P. Sandager, N. Møller, F. Sanne, F. Jan and O. Per,200664502509Gualillo, O., J.E. Caminos, M. Blanco, T.G. Caballero and M. Kojima et al.,2001142788794James, R.J.A., R.F. Drewett and T.D. Cheetham,20048938473850Judzewitsch, R.G., M.A. Pfeifer, J.D. Best, J.C. Beard, J.B. Halter and D. Porte Jr.,1982Chlorpropamide therapy of noninsulin-dependent diabetes augments basal and stimulated insulin secretion by increasing islet sensitivity to glucose.]]>55321328Kitamura, S., I. Yokota, H. Hosoda, Y. Kotani and J. Matsuda et al.,20038854735477Klok, M.D., S. Jakobsdottir and M.L. Drent, 200782134Korbonits, M., A.P. Goldstone, M. Gueorguiev and A.B. Grossman,2004252768Lanyi, E., A. Varnagy, K.A. Kovacs, T. Csermely, M. Szasz and I. Szabó,20081582733Matsuda, J., I. Yokota, M. Iida, T. Murakami and M. Yamada et al.,1999457175Monteleone, P., M. Fabrazzo, A. Tortorella, A. Fuschino and M. Maj,20027641646Murray, C.D.R., N.M. Martin, M. Patterson, S.A. Taylor and M.A. Ghatei et al.,20055416931698Nakazato, M., N. Murakami, Y. Date, M. Kojima, H. Matsuo, K. Kangawa and S. Matsukura,2001409194198Ng, P.C., C.W. Lam, C.H. Lee, G.W.K. Wonga and T.F. Fok et al., 200083F198F202Ng, P.C., C.W. Lam, C.H. Lee, W.K. Wong and T.F. Fok et al.,200154673680Ng, P.C., C.H. Lee, C.W.K. Lam, E. Wong, I.H.S. Chan and T.F. Fok,20048955635568Ng, P.C., C.H. Lee, C.W. Lam, I.H.S. Chan, E. Wong and T.F. Fok,200563217222Onal, E.E., P. Cinaz, Y. Atalay, C. Turkyilmaz and A. Bideci et al.,2004180267271Ong, K.K.L., M.L. Ahmed, A. Sherriff, K.A. Woods and A. Watts et al.,19998411451148Petridou, E., C.S. Mantzoros, M. Belechri, A. Skalkidou and N. Dessypris et al.,200562366371Pirazzoli, P., M. Lanari, S. Zucchini, M. Gennari and U. Pagotto et al.,200518379384Porstmann, T. and S.T. Kiessing, 1992150512Purnell, J.Q., D.S. Weigle, P. Breen and D.E. Cummings, 20038857475752Rohner-Jeanrenaud, F. and B. Jeanrenaud, 1996334324325Rindi, G., V. Necchi, A. Savio, A. Torsello and M. Zoli et al.,2002117511519Sahu, A., 200324225253Sainsbury, A., G.J. Cooney and H. Herzog, 200216623637Schmid, D.A., K. Held, M. Ising, M. Uhr, J.C. Weikel and A. Steiger, 20053011871192Siahanidou, T., H. Mandyla, M. Vounatsou, D. Anagnostakis, I. Papassotiriou and G.P. Chrousos,20055121312137Smith, J.T. and B.J. Waddell,200314430243030Soriano-Guillen, L., V. Barrios, J. Chowen, I. Sanchez, S. Vila, J. Quero and J. Argente,20041443035Stoll-Becker, S., J. Kreuder, I. Reiss, J. Etspuler, W.F. Blum and L. Gortner,20031538Toshinai, K., Y. Date, N. Murakami, M. Shimada and M.S. Mondal et al.,200314415061512Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold and J.M. Friedman,1994obese gene and its human homologue.]]>372425432Volante, M., E. Fulcheri, E. Allia, M. Cerrato, A. Pucci and M. Papotti,20025010131021Van der Lely, A.J., M. Tschop, M.L. Heiman and E. Ghigo,200425426457Valūniene, M., R. Verkauskien, M. Boguszewski, J. Dahlgren, D. Lasiene, L. Lasas and K.A. Wikland,200743784791Yildiz, L., B. Avci and M. Ingec,20024011141117Yokota, I., S. Kitamura, H. Hosoda, Y. Kotani and K. Kangawa,200552271276Kojima, M., H. Hosoda, Y. Date, M. Nakazato, H. Matsuo and K. Kangawa,1999402656660Masuzaki, H., Y. Ogawa, N. Sagawa, K. Hosoda and T. Matsumoto et al.,1997310291033