Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2009.1098.1101K.Ghasami A.Mohammad-Beigi 1220091215 This study was conducted to evaluate and compare the efficacy and treatment effect of sodium valprovate with propranolol and tricyclic antidepressive drugs. This piece is a rarandomized clinical trial conducted on 126 migraine patients admitted to brain and nerves clinic in Arak, Iran. Patients were divided in two groups then randomized to study treatments. Data were gathered using a checklist and a complete examination. They were analyzed by Chi square and exact test. In patients with normal and abnormal encephalogram the effectiveness rate of two treatments were 35, 61.9, 95.6 and 28.6%, respectively. This difference between two treatments was statistically significant (p<0.001). But didn't observe significant differences between two sex groups (p>0.05). For treatment and control of the migraine, in patients with normal encephalogram, propranolol with tricyclic antidepressive drugs advised and for abnormal encephalogram sodium valprovate can be the better treatment for management and reduction of headache attacks.]]>Calabresi, P., F. Galletti, C. Rossi, P. Sarchielli and L.M. Cupini,200728188195De Lissvoy G. and S.S. Lazarus,199444S56S62Diamond, S., M.E. Bigal, S. Silberstein, E. Loder, M. Reed and R.B. Lipton,200747355363Freitag, F.G., S.D. Collins, H.A. Carlson, J. Goldstein and J. Saper et al.,20025816521659Hershey, A.D., S.W. Powers, A.L. Bentti and T.J. De Grauw,200040539549Hershey, A.D. and P.K. Winner,20051052S8SLevinstein, B.,199111122123Lipton, R.B., W.F. Stewart, S. Diamond, M.L. Diamond and M. Reed,200141646657Mueller, L.L.,2007107ES1016Owens, C., B. Pugmire and K. Owens,200848267271Pascual, J., M.J. Lainez, D. Dodick and R. Hering-Hanit,200778189Silberstein, S.D.,200627410415Silberstein, S.D.,200055754762Silberstein, S.D., R.B Lipton and M. Sliwinski,199647871875Spasic, M., M. Zivkovic and S. Lukic,200310106110Stewart, W.F. and R.B. Lipton,1993134161Topczewski, A., L. Otavio and S.F. Caboclo,200868687Unalp, A., N. Uran and A. Ozturk,20082313771381Yurekli, V.A., G. Akhan, S. Kutluhan, E. Uzar, H.R. Koyuncuoglu and F. Gultekin,200893741