Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2008.882.887BadaviMohammad MehrgerdiFatemeh Zarea SarkakiAlireza Gharib NaseriMohammad Kazem DianatMahin 62008116The main objective of this study was to evaluate the
potential protective effect of red Grape Seed Extract (GSE) on lead induced
hypertension (HTN) and Heart Rate (HR) in male Wistar rats. The rats were
randomly assigned to one of 4 groups: Each group received lead acetate
(100 ppm in drinking water), GSE (100 mg kg-1, orally) or Lead
+ GSE for 45 days. Another group assigned as control group provided with
tap water and regular pellet food. The Systolic Blood Pressure (SBP) and
heart rate were determined by tail plethysmography coupled to a computer
system. There was a sustained elevation of SBP in lead exposed rats that
significantly increased at day 18 (lead treated, 112.7 ±2.7 mmHg,
vs. control, 105.6±2.6 mmHg, n = 10, p<0.05) and reached a maximum
level at day 36 (lead treated, 124.9 ±2.3 mmHg, vs. control, 103.6 ±3.1
mmHg, n = 10, p<0.001). However, the other three groups; showed no
significant changes in SBP. Furthermore, the heart rate was increased
sustainly in lead exposed animals that was statistically significant at
days 36 and 45 (lead treated group, 404.5±9.4 vs. control group,
381.7 ±6.7, n = 10, p<0.05). The blood lead level in both lead
and lead + GSE treated groups was increased significantly compared with
control and GSE treated groups (p<0.001). However, GSE administration
had no effect on the blood lead level in lead treated group. According
to the result of this study, it may be concluded that GSE could have beneficial
effect in protecting the cardiovascular system through its antioxidant
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