Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2008.607.612FirouzniaK. AmirmohseniS. GuitiM. AmanpourS. BaitollahiA. KharadmandA. Arab MohagheghiM.A. OghabianM.A. 42008114The aim of this study was to assess the T1,
T2 and T2* relaxivity of Ultrasmall Super Paramagnetic
Iron Oxide (USPIO) nano-particles in vitro and in vivo in
rat models with magnetic resonance imaging at 1.5T. First, relaxation
properties of USPIO nano-particles at different doses were measured using
related SE and GRE MR imaging protocols. The relation between dose and
relaxation were observed which is linear; Higher dose of the nano-particles
means higher relaxivity. Based on this relation, an optimum protocol can
be proposed for obtaining the best image contrast at each situation. Then
detection ability of MRI protocols was studied for USPIO nano-particles
with injection of the particles in the rat. The optimum MR protocols were
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