Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2008.2428.2432ZanbooriA. TamaddonfardE. MojtahedeinA. 1220081120In this study, effects of chlorpheniramine (H1-receptor
blocker), ranitidine (H2-receptor blocker), morphine (an opioid
agonist) and naloxone (an opioid antagonist) in separate and combined
treatments were investigated on the visceral nociception in rats. Visceral
nociception was induced by intraperitoneal injection of acetic acid (1
mL, 1%). The latency time to the beginning of the first abdominal wall
contraction (first writhe) was measured and the numbers of writhes were
counted for 1 h after acetic acid injection. Intraperitoneal injections
of chlorpheniramine and ranitidine significantly (p<0.05) increased
the latency time to the beginning of the first writhe and also significantly
(p<0.05) decreased the numbers of writhes. The same results were obtained
after subcutaneous injection of morphine. Subcutaneous injection of naloxone
did not change the intensity of visceral nociception, but significantly
(p<0.05) prevented the morphine-induced antinociception. Intraperitoneal
injection of chlorpheniramine significantly (p<0.05) enhanced the morphine-induced
analgesia, but did not reverse the effect of naloxone on nociceptive responses.
Intraperitoneal injection of ranitidine, with no effect on the morphine
-induced antinociception, significantly (p<0.05) reversed the effect
of naloxone on pain responses. These results suggest that both chlorpheniramine
and ranitidine exert antinociceptive effect in the visceral nociception.
In addition, morphine through a naloxone-dependent mechanism produces
visceral antinociception. Moreover, the endogenous opioid system may participate
in the chlorpheniramine- but not in the ranitidine-induced antinociception.]]>Abacioglu, N., A. Bediz, I. Cakici, B. Tuncutan and I. Kanzik,19931- and H2-antihistaminics in mice.]]>2411731176Al-Chear, E.D. and R.J. Traub,200296221225Akoev, G.N., L.V. Fillipova and N.O. Sherman,19967111631166Ananthan, S., 20068E118E125Cannon, K.F., R. Leurs and L.B. Hough,200788122129Coruzzi, G., M. Adami, E. Guaita, I.J. De Esch and R. Leurs,20074-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation.]]>563240244Fu, L.W., W. Schunack and J.C. Longhurst,20051 receptors and PKC.]]>93713722Gallantine, E.L. and T.F. Meert,200479125135Girard, P., Y. Pansart, M.C. Coppe, D. Verniers and J.M. Gillardin,20045036369Gogas, K.R. and L.B. Hough,19892-antagonists.]]>248262267Ting, E., R.C. Roveroni, L.F. Ferrari, C.M. Lotufo and M.C. Veiga et al.,200781765771Ikeda, Y., A. Ueno, H. Naraba and S. Oh-ishi,20016929112919Janig, W. and H.J. Habler,200216429446Kreis, M.E., W. Haupt, A.J. Kircup and D. Grundy,199838G675G680Lang, E., A. Novak, P.W. Reeh and H.O. Handwerker,1990in vitro.]]>63887901Le Bars, D.L., M. Gozariu and S.W. Cadden,200153597652Leza, J.C., I. Lizasoian and P. Lorenzo,19901-and H2-histamine receptor blockers and opiate analgesia in mice.]]>12671678Malbec, O., K. Roget, C. Schiffer, B. Iannascoli, A.R. Dumas, M. Arock and M. Daeron,2007in vitro model of mature serosal-type mouse mast cells.]]>17864656475Mobarakeh, J.I., S. Sakurada, T. Hayashi, T. Orito and K. Okuyama et al.,20021 receptor gene knockout mice.]]>4210791088Mobarake, J.I., S. Sakurada, S. Katsutama, M. Kutsuwa, A. Kuramasu and Z.Y. Lin et al.,20003918189Mobarake, J.I., K. Takahashi, S. Sakurada, A. Kuramasu and K. Yanai,20062 receptor gene knockout mice.]]>51612622Ness, T.J.,199940119128Olsen, U.B., C.T. Eltrop, B.K. Ingvargsen, T.K. Jorgensen, J.A. Lundbaek, C. Thomsen and A.J. Hansen,20024354357Rangachari, P.K.,1992262G1G13Reichert, J.A., R.S. Daughters, R. Rivard and D.A. Simone,200189221227Suzuki, T., K. Takamori, Y. Takahashi, M. Narita, M. Misawa and K. Onodera,199454203211Tajik, H., E. Tamaddonfard and N. Hamzeh-Gooshchi,200811312314Tamaddonfard, E. and A. Mojtahedin,200459373378Tamaddonfard, E., H. Tajik and N. Hamzeh-Gooshchi,200864883885Trescot, A.M., S. Datta, M. Lee and H. Hansen,200811S133S153Wong, C.L.,198576974Yoshimatsu, M. and H. Furue,2006101107117