Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2008.2308.2313Pterodon pubescens
Seeds Ethanolic Extract]]>CardosoC.C. PintoA.C. MarquesP.R. GayerC.R.M. AfelM.I.R. CoelhoM.G.P. SabinoK.C.C. 1220081119The anti-arthritic property of hydro alcoholic extract
of Pterodon pubescens seeds was previously demonstrated using the
Collagen Induced Arthritis (CIA) in mice, the most similar arthritis experimental
model to human rheumatoid arthritis. This disease is characterized by
chronic inflamed joints resulting from exacerbated functions of macrophages
and T and B lymphocytes. Anti-inflammatory and antinociceptive activities
by ethanolic extract of Pterodon pubescens seeds (EEPp) have been
also reported. This study describes the effects of EEPp on T and B lymphocytes
functions from healthy mice. Delayed Type Hypersensitivity (DTH), in
vivo antibody production, T and B lymphocyte proliferation and NO
production were determined. Mice treated orally for 7 days with EEPp had
inhibited 58% of B cell antibody production (10-3 mg kg-1
b.wt.) and 33% of the DTH response (10-4 mg kg-1
b.wt.), also reducing tissue leukocyte infiltration. EEPp (10-2
mg mL-1) also inhibited in vitro T (89%) and B (68%)
lymphocytes proliferation and NO production (53%) by macrophage cell line
J774. The immunosuppression here described for EEPp supports its potential
therapeutic use to control exacerbated humoral and/or cellular immune
response as in autoimmune and chronic inflammatory diseases.]]>Coelho, M.G.P., P.R. Marques, C.R.M. Gayer, L.C.A. Vaz, J.F. Nogueira Neto and K.C.C. Sabino,2001Pterodon pubescens seeds in mice with collagen-induced arthritis.]]>77159164Coelho, M.G.P., K.C.C. Sabino and S.R. Dalmau,2004Pterodon pubescens) seed infusion on collagen-induced arthritis.]]>22213218Coelho, L.P., P.A. Reis, F.L. Castro, C.R.M. Gayer and C.S. Lopes et al.,2005Pterodon pubescens Benth.]]>98109116Dhuley, J.N.,1997581520Di Rosa, M., M. Radomski, R. Carnuccio and S. Moncada,199017212461252Ghazanfari, T., Z. Hassan and M. Ebrahimi,2002215411549Kobayashi, K., K. Kaneda and T. Kasama,200153241245Millan, S., M.I. Gonzalez-Quijano, M. Giordano, L. Soto, A.I. Martin and A. Lopez-Calderon,19965914311442Mosmann, T.,1983655563Sabino, K.C.C., C.R.M. Gayer, L.C.A. Vaz, L.R.L. Santos, I. Felzenszwalb and M.G.P. Coelho,1999In vitro and in vivo toxicological study of the Pterodon pubescens seed oil.]]>1082735Sabino, K.C.C., F.A. Castro, J.C.R. Oliveira, S.R.A. Dalmau and M.G.P. Coelho,1999Pterodon pubescens.]]>13613615Silva, M.C.C., C.R.M. Gayer, C.S. Lopes, N.O. Calixto and P.A. Reis et al.,2004Pterodon pubescens.]]>55135141Yamaguchi, H.,1992319287297