Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2008.2036.2039UllahM. Obayed UddinM. Jashim HamidK. KabirS. RahmanM. Azizur ChoudhuriM.S.K. 1220081116The study was carried out to investigate the safety
profile as well as the effect of Rohitakarista (RHT) on various
biochemical parameters of rats` plasma after chronic administration. RHT,
a classical Ayurvedic preparation used in hepatosplenic disorders, was
administered per oral route at a dose of 100 mg kg-1 body weight,
once daily, up to 46 days for all the experiments. Forty albino rats (Rattus
novergicus: Sprague-Dawley strains), equally of both sexes, were randomly
grouped into four where each group had ten animal/sex. One male and one
female group were used as control and other groups were used as test.
In the male, rats there was a statistically insignificant increase (p
= 0.763) in the total protein but there was a statistically significant
increase (p = 0.022) in the total protein content of the plasma of female
rats. Statistically very high significant increase (male: p = 0.001 and
female: p = 0.001) in the albumin content of the plasma was noted in both
sexes. In case of bilirubin, interestingly it was decreased very high
significantly (p = 0.001) in plasma of male rats but increased very high
significantly (p = 0.001) in the plasma of female rats. In the male rats,
statistically there was a very high significant decrease (sGPT: p = 0.001,
sGOT: p = 0.001 and ALP: p = 0.001) in the sGPT, sGOT and ALP activities
in the plasma. On the other hand, statistically there was a very highly
significant increase (sGPT: p = 0.001, sGOT: p = 0.001 and ALP: p = 0.001)
in the sGPT, sGOT and ALP activities in the plasma of female rats. Very
high significant decrease (male: p = 0.001 and female: p = 0.001) in creatinine
in plasma of both sexes were observed after chronic administration of
RHT. Urea in the plasma was decreased very high significantly (p = 0.001)
in plasma of male rats but increased very high significantly (p = 0.001)
in the plasma of female rats. There was high significant increase (p =
0.002) in uric acid in male rats. On the contrary, no significant increase
(p = 0.324) of uric acid was observed in female rats.]]>Ghani, A.,20032nd Edn.,Pages: 603Pages: 603Kaplan, A.,19651965pp: 245-256pp: 245-256Naganna, B.,19891989pp: 59-61pp: 59-61Bhau, B.S., M.S. Negi, S.K. Jindal, M.S. and M. Lakshmikumaran,2007Tecomella undulata (Sm.). An endangered tree species using amplified fragment length polymorphisms-based.]]>936772Doumas, B.T., W.A. Watson and H.G. Biggs,1971318796Glasnapp, D.R. and J.P. Poggio,19851st Edn.,Plummer, D.T.,19712nd Edn.,pp: 144-145pp: 144-145Ahmad, F., R.A. Khan and S. Rasheed,1994Celastrus paniculatus and Tecomella undulate for analgesic and anti-inflammatory activities.]]>42193198Mitchell, F.L., N. Veall and R.W.E. Watts,19729120Jagetia, G.C., K.J. Malagi. M.S. Baliga, P. Venkatesh and R.R. Veruva,200410971978Umezawa, H. and I.R. Hooper,19821st Edn.,Zilva, J.F., P.R. Panmall and P.D. Mayne,19915th Edn.,Parekh, J. and S.V. Chanda,2007In vitro antimicrobial activity and phytochemical analysis of some Indian medicinal plants.]]>315358Evelyn, K.A. and H.T. Malloy,1938126655662Ali, M.,19981st Edn.,Azam, M.M.,1999Tecomella undulata, Orient.]]>15375377Shahjahan, M., K.E. Sabitha, M. Jainu and C.S. Shyamala-Devi,2004Solanum trilobatum against carbon tetrachloride induced hepatic damage in albino rats.]]>120194198Tietz, N.W., E.L. Prude and O. Sirgard-Anderson,19942nd Edn.,pp: 1354-1374pp: 1354-1374Wright, P.J. and D.T. Plummer,1974236573Kind, P.R.N. and E.J. King,19547322326Evans, W.C.,20025th Edn.,pp: 119-159pp: 119-159