Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2008.1785.1790SakhaK. HusseiniM.B. SeyyedsadriN. 1220081114The goal of this study was to investigate the role of
procalcitonin (PCT) in diagnosis of neonatal sepsis and its correlation
with C-Reactive Protein (CRP). One hundred and seventeen neonates with
the gestational age ≥35 weeks with clinically suspected diagnosis of
neonatal sepsis were studied during one year from 2007 in Tabriz Children`s
Hospital. Conventional sepsis workup was done in all cases and the diagnosis
of neonatal sepsis was proved based on the results of blood culture. The
serum procalcitonin was measured by quantitative Chemo-luminance methods
and the results were compared with CRP levels between the neonates with
and without proven sepsis. The results showed among in 117 neonates with
suspected sepsis 27 (23.1%) cases have positive blood culture (proven
sepsis). The mean levels of PCT in neonates with and without proven sepsis
was 4.42 ±6.66 vs. 2.06 ±4.03 ng mL-1 and CRP
33.98 ±36.81 vs. 12.30 ±20.42 mg L-1 were significantly
higher in neonates with proven sepsis (p = 0.026 and p <0.001). The
sensitivity, specificity, positive predictive value and negative predictive
value of PCT (more than 2 ng mL-1) were 66.7, 50, 28.6, 83.3
and CRP (more than 3.5 mg L-1) were 70.4, 72.2, 43.2 and 89%,
respectively, in diagnosis of neonatal sepsis. There was a meaningful
correlation between the level of PCT and CRP in the sepsis group (r =
0.797, p <0.001). The results of the current study showed that more
relying on the level of PCT and CRP for planning the management of neonates
with suspected sepsis is not logical, but a negative result may be helpful
in ruling it out.]]>Blommendahl, J., M. Janas, S.Laine, A. Miettinen and P. Ashorn,200234620622Boo, N.Y., A.A. Nor Azlina and J. Rohana,200849204208Ballot, D.E., O. Perovic, J. Galpin and P.A. Cooper,200494851854Chiesa, C., A. Panero, N. Rossi, M. Stegagno, M. De Giusti, J.F. Osborn and L. Pacifico,199826664672Dandona, P., D. Nix, M.F. Wilson, A. Aljada, J. Love, M. Assicot and C. Bohuon,19947916051608Franz, A.R., M. Kron, F. Pohlandt and G. Steinbach,199918666671Ghillani, P.P., P. Motte and F. Troalen,19894968456851Gendrel, D. and C. Bohuon,200019679687Hodge, G., S. Hodge, R. Haslam, A. McPhee, H. Sepulveda, E. Morgan, I. Nicholson and H. Zola,2004137402407 Hodge, G., S. Hodge, P. Han and R. Haslam,2004135125129Hatherill, M., S.M. Tibby, K. Sykes, C. Turner and I.A. Murdoch,199981417421Jaye, D.L and K.B. Wsites,199716735747Joram, N., C. Boscher, S. Denizot, V. Loubersac, N. Winer, J.C. Roze and G.C. Gras-Le,200691F65F66Koskenvuo, M.M., K. Irjala, A. Kinnala, O. Ruuskanen and P. Kero,200322377378Kocabas, E., A. Sarikcioglu, N. Aksaray, G. Seydaoglu, Y. Seyhun and A. Yaman,200749720Lapillonne, A., E. Basson, G. Monneret, J. Bienvenu and B.L. Salle,199835112111212Muller, B., J.C. White, E.S. Nylen, R.H. Snider, K.L. Becker and J.F. Habener,200186396404Monneret, G., J.M. Labaune, C. Isaac, F. Bienvenu, G. Putet and J. Bienvenu,199786209212Polin, R.A.,200614334Perez Solis, D., J.B. Lopez Sastre, G.D. Coto Cotallo, M.A. Dieguez Junquera, E.M. Deschamps Mosquera and M. Crespo Hernandez,200664349353Angus, D.C. and R.S. Wax,200129S109S116Turner, D., C. Hammerman, B. Rudensky, Y. Schlesinger and M.C. Schimmel,20069515711576Vazzalwar, R., E. Pina-Rodrigues, B.L. Puppala, D.B. Angst and L. Schweig,200525397402Lopez Sastre, J.B., D. Perez Solis, V.R. Serradilla, B.F. Colomer and G.D. Coto Ccotallo,2007799Whicher, J., J. Bienvenu and G. Monneret,200138483493