Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2008.1779.1784HaidariFatemeh RashidiMohammad Reza KeshavarzSeid Ali MahboobSoltan Ali EshraghianMohammad Reza ShahiMajid Mohamad 1220081114The aim of this study was to investigate the effects
of onion on serum uric acid levels and hepatic Xanthine Dehydrogenase/Xanthine
Oxidase activities in normal and hyperuricemic rats. Hyperuricemia was
induced by intraperitoneal injection of 250 mg kg-1 potassium
oxonate in rats. Oral administration of onion at 3.5 and 7.0 mg kg-1
day-1 for 7 days was able to reduce serum uric acid levels
in hyperuricemic rats with no significant effects on the level of this
compound in the normal animals. In addition, onion when tested in vivo
on rat liver homogeneities elicited significant inhibitory actions on
the Xanthine Dehydrogenase (XDH) and Xanthine Oxidase (XO) activities.
This effect resulted less potent than that of allopurinol. However, the
hypouricemic effect observed in the experimental animal did not seem to
parallel the change in XDH and XO activities, implying that the onion
might be acting via other mechanisms apart from simple inhibition of enzyme
activities. Such hypouricemic action and enzyme inhibitory activity of
onion makes it a possible alternative for allopurinol, or at least in
combination therapy to minimize the side-effects of allopurinol, in particular
in long-term application.]]>Caridi, D., V.C. Trenerry, S. Rochfort, S. Duong, D. Laugher and R. Jones,2007Allium cepa L.) varieties using capillary zone electrophoresis and high performance liquid chromatography.]]>105691699Carroll, J.J., H.C. Roberta Douglass and A.L. Babson,197117158160Choi, H.K. and E.S. Ford,2007120442447Fels, E. and J.S. Sundy,200820198202Finnegan, J.R., B. Rooney, K. Viswanath, P. Elmer, K. Graves, J. Baxter, J. Hertog, R. Mullis and J. Potter,199219233248Franzese, T.A.,20042004pp: 980-982pp: 980-982Hall, I.H., J.P. Scoville, D.J. Reynolds, R. Simlot and P. Duncan,19904619231927Hertog, M.G.L., P.C.H. Hollman, M.B. Katan and D. Kromhout,1993202129Kinoshita, T., Z. Lepp, Y. Kawai, J. Terao and H. Chuman,200626179188Kong, L.D., C. Yang, F. Ge, H.D. Wang and Y. Song Guo,200493325330Lee, S.J. and R.A. Terkeltaub,19968224230Lin, C.M., C.S. Chen, C.T. Chen, Y.C. Liang and J.K. Lin,2002294167172Liote, F., 20035227234Miean, K.H. and S. Mohamed,20014931063112Muraoka, S. and T. Miura,200393284289Murota, K. and J. Terao,20034171217Nguyen, M.T.T., S. Awale, Y. Tezuka, Q.L. Tran, H. Watanabe and S. Kadota,20042714141421Nuki, G.,200634417423Okamoto, K.,200866748753Potapovich, A.I. and V.A. Kostyuk,200368514519Slimestad, R., T. Fossen and I.M. Vagen,2007551006710080Smith, P.K., R.I. Krohn, G.T. Hermanson, A.K. Mallia and F.H. Gartner et al.,19851507685Stavric, B., S. Clayman, R.E.A. Gradd and D. Hebert,1975in vivo effects in the rat induced by chlorprothixene and potassium oxonate.]]>7117124Stinefelt, B., S.S. Leonard, K.P. Blemings, X. Shi and H. Klandorf,2005353745Strazzullo, P. and J.G. Puig,200717409414Terkeltabu, R.,2006648286Van Hoorn, D.E.C., R.J. Nijveldt, P.A.M. Van Leeuwen, Z. Hofman, L. M’Rabet, D.B.A. De Bont and K. Van Norren,2002451111118Wang, Y., J.X. Zhu, L.D. Kong, C. Yang, C.H.K. Cheng and X. Zhang,200494232237Yoshisue, K., H. Masuda, E. Matsushima, K. Ikeda, S. Nagayama and Y. Kawaguchi,20002811621167Yu, Z., W.P. Fong and C.H. Cheng,200735981986Zhao, X., J.X. Zhu, S.F. Mo, Y. Pan and L.D. Kong,2006103357365Zhu, J.X., Y. Wang, L.D. Kong, C. Yang and X. Zhang,2004Biota orientalis extract an dits flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver.]]>93133140