Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2008.1764.1767RafeeyMandana GolzarAli JavadzadehAlireza 1220081113This study aimed to provide the analysis of clinical presentation,
results of laboratory and imaging investigations as well as clinical outcome
of children with cholestasis. Infants with neonatal cholestasis referred
to Children`s Hospital from 2002 to 2007 were participated in the study
in a cross-sectional prospective study. Appropriate diagnostic criteria
and tests were employed for diagnosis the underlying etiologies of neonatal
cholestasis. One year mortality rate was determined. One hundred twenty
one infants, 75 males and 46 females, with the mean age of 58.3 ±15.3 (14-120) days were enrolled in study. Jaundice (94.2%) and hepatomegaly
(66.1%) were the most frequent symptom and signs on admission. Idiopathic
neonatal hepatitis (36.4%), extrahepatic biliary atresia (24.8%), metabolic
disease (20.7%), intrahepatic ductal paucity (10.7%), intrauterine infection
(3.3%) were the most frequent causes of neonatal cholestasis. One year
mortality was 5.8%. There is still not one effective and specific diagnostic
method in differentiating between the causes of cholestasis in the newborns
and infants. Some potentially important differences in the disease pattern,
initial presentation and long-term outcome are suggested from the present
study when compared to previous reports from other parts of the world.]]>Aanpreung, P., M. Laohapansang, R. Ruangtrakool and J. Kimhan,200588S9S15Bazlul Karim, A.S. and M. Kamal,2005245254Kelly, D.A. and A. Stanton,199531011721173Lee, W.S.,2008445761Maclin, V.A.B.W.F.,20042004pp: 1080-1093pp: 1080-1093McKiernan, P.J.,20027153165Mieli-Vergani, G., E.R. Howard, B. Portman and A.P. Mowat,198925421423Mowat, A.P., H.T. Psacharopoulos and R. Williams,197651763770Moyer, V., D.K. Freese, P.F. Whitington, A.D. Olson, F. Brewer, R.B. Colletti and M.B. Heyman,200439115128Najafi, M., A. Khodadad, G.R. Khatami, F. Farahmand, G.H. Falahi and F. Motamed,200616289294Nayak, N.C. and N. Vasdev,200239421425Sokol, R.J., C. Mack, M.R. Narkewicz and F.M. Karrer,200337421Stormon, M.O., S.F. Dorney, K.R. Kamath, E.V. O'Loughlin and K.J. Gaskin,2001374750Venigalla, S. and G.R. Gourley,200428348355Yachha, S.K.,2005244748Yachha, S.K., A. Khanduri, M. Kumar, S.S. Sikora, R. Saxena, R.K. Gupta and J. Kishore,199633729734