Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2008.1696.1701BoulbaroudS. MesfiouiA. ArfaouiA. OuichouA. El HessniA. 1220081113A study was designed to examine the effects of dietary
flaxseed oil (FO) and sesame oil (SO) which are rich successively in n-3
and (n-9 and n-6) on biochemical parameters and histological status of
bone. Sixty-four 90-day-old female wistar rats were randomly assigned
to 6 groups: sham-operated rat (sham)+ control diets, ovariectomized rat
(OVX))+ control diets, OVX+ 7% FO, OVX+ 7% SO, OVX+ 10% FO, OVX+ 10% SO.
After 4 weeks of treatments, rats were euthanized; blood and tissues were
collected for analyses. Markers of bone formation which is alkaline phosphatase
activity and markers of bone resorption which is tartrate resistant acid
phosphatase activity were measured. Present results showed that OVX increased
significantly ALP and TRAP activity and the examination of bone tissue
showed disruptive and lytic bone trabeculae. Animals fed 10% FO and 10%
SO of fat reduced these parameters and improved bone microarchitecture.
Whereas, there was no improvement in biochemical and histological states
in OVX rats that received 7% of PUFAs successively provided from FO and
SO diets. In conclusion, our results are encouraging because they suggest
that PUFAs intake may help to prevent osteoporosis associated with estrogens
deficiency. However, further studies are needed to determine the mechanism
by which a diet rich in n-3 or lignans modulate bone tissue.]]>Caughey, G.E., E. Mantzioris, R.A. Gibson, L.G. Cleland and M.J. James,199663116122Chavali, S.R. and R.A. Forse,199961347352Chavali, S.R., W.W. Zhong, T. Utsunomiya and R.A. Forse,1997114153160Claassen, N., H.C. Potgieter, M. Seppa, W.J. Vermaak, H. Coetzer, D.H. Van Papendorp, M.C. Kruger,199516385S392SGreen, K.H., S.C. Wong and H.A. Weiler,200471121130Griel, A.E., P.M. Kris-Etherton, K.F. Hilpert, G. Zhao, S.G. West and R.L. Corwin,2007622Iwami-Morimoto, Y., K. Yamaguchi and K. Tanne,199969365371Kelley, D.S.,19951995pp: 145-156pp: 145-156Kelly, O., S. Cusack, C. Jewell and K.D. Cashman,200390743750Li, Y., R.S. Greiner, N. Salem and B.A. Watkins,200338683686Lucas, E.A., R.D. Wild, L.J. Hammond, D.A. Khalil, S. Juma, B.P. Daggy, B.J. Stoecker and B.H. Arjmandi,20028715271532Raisz, L.G.,19997419421Sakaguchi, K., I. Morita and S. Murota,1994508184Shen, C.L., J.K. Yeh, J. Rasty, M.C. Chyu, D.M. Dunn, Y. Li and B.A. Watkins,200780286293Shimizu, S., K. Akimoto, H. Kawashima, M. Sugano and H. Yamada,199126512516Suja, K.P., J.T. Abraham, S.N. Thamizh, A. Jayalekshmy and C. Arumughan,200484393400Sun, D., A. Krishnan, K. Zaman, R. Lawrence, A. Bhattacharya and G. Fernandes,20031812061216Utsunomiya, T., S.R. Chavali, W.W. Zhong and R.A. Forse,2000ex vivo production of lipopolysaccharide-induced prostanoids and tumor necrosis factor α in rats.]]>72804808Wallace, F.A., E.A. Miles and P.C. Calder,200389679689Watkins, B.A., Y. Li, K.G. Allen, W.E. Hoffmann and M.F. Seifert,200013022742284Watkins, B.A., Y. Li and M.F. Seifert,200617282289Watkins, B.A., C.L. Shen, K.G. Allen and M.F. Seifert,19961113211332Weiler, H., H. Kovacs, E. Nitschmann, S. Fitzpatrick Wong, N. Bankovic-Calic and M. Ogborn,200217795799Wu, D., S.N. Meydani, M. Meydani, M.G. Hayek, P. Huth and R.J. Nicolosi,199663273280Xu, H., B.A. Watkins and H.D. Adkisson,199429619625