Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2008.1093.1099N. sativa Oil on Impaired Glucose Tolerance and Insulin
Insensitivity Induced by High-Fat-Diet and Turpentine-Induced Trauma]]>AlsaifMohammed A.82008118The aim of this study was to investigate the effect of N. sativa
oil on impaired glucose tolerance and insulin insensitivity induced
by high-fat diet and trauma. Three dietary groups were used in this study;
Rat-Chow (RC), N. sativa oil diet (Combination 4% N. sativa
oil and 16% butter oil) (NSOD) and 20% Butter Oil Diet (BOD). Each group
was subdivided in two groups; control and trauma. Diets were supplemented
for five consecutive weeks body weight increase per week was calculated.
At end of the dietary treatments, single dose (2 mL kg-1 body
weight) of turpentine was injected in the dorso-lumber region. Intravenous
glucose tolerance test (iv GTT) was performed, insulinogenic index and
insulin sensitivity was measured. The results showed butter oil diet significantly
increased the body weights and visceral fats compared other two groups,
respectively. Fasting glucose levels did not change in trauma induced
rats while insulin levels increased significantly and it found highest
in butter oil diet fed animals. Impaired glucose tolerance was found sever
in BOD fed traumatized rats. N. sativa oil diet protected impaired
glucose tolerance and insulin insensitivity induced either via saturated
fatty acids or injury. In conclusion, N. sativa oil may be used
in post surgery diabetic patients to prevent the long going adverse effects
from surgical trauma.]]>Al-Hader, A., M. Aqel and Z. Hasan,1993Nigella sativa seeds.]]>3196100Ali, B.H. and G. Blunden,2003Nigella sativa.]]>17299305Alsaif, M.A. and M.M.S. Duwaihy,200424417425Alsaif, M.A.,200435663Barton, R.N. and B.J. Passingham,198086363370Black, P.R., D.C. Brooks, P.Q. Bessey, R.R. Wolfe and D.W. Wilmore,1982196420435Bloomgarden, Z.T.,199922517522Davidson, M.B. and D. Garvey,1993264E18E23Davies, J.W.L.,1982De Luca, C. and J.M. Olefsky,200858297105El-Dakhakhny, M., N.J. Madi, N. Lembert and H.P. Ammon,2002Nigella sativa oil, nigellone and derived thymoquinone inhibit synthesis of 5-lipoxygenase products in polymorphonuclear leukocytes from rats.]]>81161164El-Dakhakhny, M., N. Mady, N. Lembert and H.P.T. Ammon,2002Nigella sativa oil is mediated by extrapancreatic actions.]]>68465466Fararh, K.M., Y. Atoji, Y. Shimizu and T. Takewaki,2002Nigella sativa oil in streptozotocin plus Nicotinamide diabetic hamster.]]>73279-282282Fararh, K.M., Y. Atoji, Y. Shimizu, T. Shiina, H. Nikami and T. Takewaki,2004Nigella sativa L. oil in streptozotocin-induced diabetic hamsters.]]>77123129Frayn, K.N.,198624577599Houghton, P.J., R. Zarka, B. de las Heras and J.R.S. Hoult,1995Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation.]]>613336Kaleem, M., D. Kirmani, M. Asif, Q. Ahmed and B. Bano,2006Nigella sativa L. seeds in diabetic rats.]]>44745748Kanter, M., I. Meral, Z. Yener, H. Ozbek and H. Demir,2003Nigella sativa L. in streptozotocin-induced diabetic rats.]]>210213219Kinney, J.M.,19771977Lovejoy, J.C., C.M. Champagne, S.R. Smith, J.P. DeLany, G.A. Bray and M. Lefevre,2001508692Mizock, B.A.,1995897584Pan, D.A., A.J. Hulburt and L.H. Storlien,199412415551565Petersen, K.F., S. Dufour, D. Befroy, R. Garica and G.I. Shulman,2004350664671Ramirez, R., J.M. Lopez, F.J. Bendoya and R. Goberna,199015179183Richid, H., H. Chevassus, R. Nmila, C. Giral, P. Petit, M. Chokairi and Y. Sauvaire,200418525529Storlien, L.H., A.B. Jenkins, D.J. Chisholm, W.S. Pascoe, S. Khouri and E.W. Kraegen,199140280289Storlien, L.H., D.A. Pan, M. Milner and S. Lillioja,1993177S77SStrommer, L., M. Wickbom, F. Wang, M.K. Herrington, C.G. Ostenson, U. Arnelo and J. Permert,2002147825833Thorell, A., S. Efendic, M. Gutniak, T. Haggmark and O. Ljungqvist,1994815963Virkamaki, A. and H. Yki-Jarvinen,199413420722078Wiersma, M.M., I.M. Bakker and J.K. Radder,1993pp: 228-236pp: 228-236Woloski, B.M.R.N.J. and J.C. Jamieson,1987861519Woolfson, A.M.J., R.V. Heatly and S.P. Allison,19771977Wusteman, M., D.G.D. Wight and M. Elia,1990259E763E769Zaoui, A., Y. Cherrah, N. Mahassini, K. Alaoui, H. Amarouch and M. Hassar,2002Nigella sativa fixed oil.]]>96974