Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2007.828.830 Picralima nitida for Hypoglycaemic Activity]]>IgboasoiyiA.C. EssienE.E. EseyinO.A. UbamG. 52007105The seed extract of picralima nitida was screened for hypoglycaemic activity. The hypoglycaemic activity was evaluated in both normoglycemic and alloxan-induced diabetic rats, using glibenclamide as a reference drug. In both normoglycaemic and alloxan diabetic groups, 250 mg kg-1 of the extract, 5 mg kg-1 glibenclamide and a mixture of the extract (125 mg kg-1 ) and glibenclamide (2.5 mg kg-1) were administered orally, respectively. Blood glucose was measured with a glucometer at 0, 1, 2 and 4 h. In the sub acute group, the same doses as above were administered to diabetic rats once daily for 14 days and blood glucose was determined on days 1, 5, 10 and 15. The seed extract did not show any hypoglycaemic effect in both normoglycaemic and alloxan diabetic rats. Rather, the extract increased blood glucose concentration in the sub acute group on days 5, 10 and 15. These results indicate that, unlike the fruit pulp, the seed extract of Picralima nitida did not possess hypoglycaemic activity.]]>Ansa-Asamoah, R., G.J. Kapadia, H.A. Lloyed and E.A. Sokoski,1990picralima nitida seeds.]]>53975977Arens, H., H.O. Borbe, B. Ulbrich and J. Stoeckigt,1982picralima nitida cell suspension culture by opiate receptor binding studies.]]>46210214Francois, G., L.A. Assi, J. Holenz and G. Bringmann,1996Picralima nitida display pronounced inhibitory activities against asexual erythrocytic forms of Plasmodium falciparumin vitro.]]>54113117Inya-Agha, S.I.,1999Picralima nitida.]]>36667Iwu, M.M. and D.L. Klayaman,1992in vitro antimalarial activity of Picralima nitida extracts.]]>36133135Iwu, M.M., D.I. Klayman, G.T. Bass, S.T. Andersen and B.G. Schuster,1992Picralima nitida.]]>47179179Iwu, M.M., J.E. Jackson, J.D. Tally and D.L. Klayman,199258436441Kspsdia, G.J., C.K. Angerlofer and A.R. Ansa,1993Picralima nitida seeds.]]>59565566Levy, A. and M.C. Collin,1978Picralima nitida Apocynaceae.]]>367783Magilu, M., M. Mbuyi and M.B. Ndele, 19961996pp: 741-746pp: 741-746Menzies, J.R.W., S.J. Paterson, M. Duwiejua and A.D. Corbett,1998Picralima nitida ,(fam. Apocynaceae).]]>350101108Moeller, B.L., L. Seedorff and F. Nartey,1972Picralima nitida.]]>1126202621Omino, E.,19961996Wosu, L.O. and C.C. Ibe,1989Picralima nitida bark in the treatment of experimental trypanosomiasis: A preliminary study.]]>25263268