Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2007.617.621C. Patrick-IwuanyanwuK. O. WegwuM. O. AyaloguE. 42007104The hepatoprotective effects of garlic
(Allium sativum), ginger (Zingiber officinale) and vitamin
E pre-treatment against carbon tetrachloride (CCl4)-induced
liver damage in male wistar albino rats were investigated. Carbon tetrachloride
(0.5 mL kg-1 body weight) was administered after 28 days of
feeding animals with diets containing ginger, garlic, vitamin E and various
mixtures of ginger and garlic. Serum alanine amino transferase, aspartate
amino transferase and alkaline phosphatase levels, 24 h after CCl4
administration, decreased significantly (p≤0.05) in rats pre-treated
with garlic, ginger, vitamin E and various mixtures of garlic and ginger
than in CCl4-treated rats only. Lipid peroxidation expressed
by serum malondialdehyde (MDA) concentration was assayed to assess the
extent of liver damage by CCl4; including the extent of hepatoprotection
by garlic, ginger and vitamin E. MDA concentration was significantly decreased
(p≤0.05) in rats pretreated with garlic, ginger, vitamin E and various
mixtures of garlic and ginger than in rats administered CCl4-alone.
Histological examination of the liver revealed severe infiltration of
inflammatory cells in rats treated with CCl4 alone. However,
the observed alteration in the normal architecture of the hepatic cells
decreased remarkably in pre-treated rats.]]>Ahmed, R.S. and S.B. Sharma,1997Allium sativum Linn.) and ginger (Zingiber officinale Rosc.) in albino rats.]]>35841843Albano, E., G. Bellomo, R. Carini, F. Biasi, G. Poli and M.U. Dianzani,1985192184188Artizzu, M. and M.U. Dianzani,196263453464Brattin, W.J., S.D. Pencil, R.L. Waller, E.A. Glende and O. Recknagel,198457321323Dianzani, M.U.,19911991pp: 327-400pp: 327-400Gutteridge, J.M.C. and S. Wilkins,1982137327340Hukkeri, V.I., B. Jaiprakash, M.S. Lavhale, R.V. Karadi and I.J. Kuppast,2002Anthus excelsa Roxb. Leaf extracts on experimental liver damage in rats.]]>11120128Hunter, F.E., J.M. Gebicki, P.E. Hoffstein, J. Weinstein and A. Scott,1963238828835Johnson, D.E. and C. Kroening,19984 in cultural rat hepatocytes.]]>83231239Junnila, M., T. Rahko, A. Sukura and L.A. Lindberg,200037231238Koji, H., K. Shigotoghi, B. Purusotam and N. Tsuneo,1966C. argentea.]]>10387392Lin, J.K. and C.J. Wang,19867595599Mustafa, T. and K.C. Srivastava,1990Zingiber officinale) in Migraine headache.]]>29267273Ngaha, E.O., M.A. Akanji and M.A. Madusolomo,198945143146Obi, F.O., I.A. Usenu and J.O. Osayande,1998H. rosasinensis anthocyanin extract administered methanol.]]>1319398Obi, F.O., L.A. Omogbai, O.S.J. Oriafo and O.D. Ovat,2001558Poli, G., E. Albano and M.U. Dianzani,198745117142Raghavendran, B.R.H., A. Sathivel and T. Devaki,2003504246Recknagel, R.O.,196719145208Reynolds, E.S., R.E. Thiers and B.L. Vallee,196223735463551Shenoy, K.A., S.N. Somayaji and K.L. Bairy,200133260266Siegers, C.P., W. Horn and M. Younes,1985568186Zar, J.H.,1984Pages: 620Pages: 620