Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2007.498.501Telfairia occidentalis
in Rat]]>A. EseyinOlorunfemi EbongPatrick EkpoArit IgboasoiyiArnold OforahEmmanuel 32007103The blood glucose lowering effect of the ethanolic extract of the
seed of Telfaria occidentalis in normoglycemic, alloxan-diabetic
and glucose loaded rats was determined. Ethanolic extract of the seed
of Telfairia occidentialis was administered at two dose levels
(100 and 250 mg kg-1) to both normoglycemic and alloxan diabetic
Wilstar albino rats. Blood was collected from the tail vein of the rats
at 1, 2 and 4 h. Oral Glucose Tolerance Test (OGTT) was carried out by
administering 100 and 250 mg kg-1 of the extract to glucose
loaded rats (1 g kg-1) and blood was collected from the tail
vein of rats at 0, 15, 30, 45 and 60 min. Blood glucose level was determined
using a glucometer. Standard methods were used for phytochemical screening
of the extract. The results showed that 100 mg kg-1 ethanolic
extract of seed of T. occidentalis reduced blood glucose concentration
significantly only in the alloxan diabetic and not in the normoglycemic
rats. 250 mg kg-1 extract did not show this effect. The extract
did not affect the oral glucose tolerance of rats when administered simultaneously
or 1 h before glucose loading. Phytochemical screening indicated the presence
of alkaloids, steroids, tannins and terpenes. It could be concluded that
the ethanolic extract of the seed of Telfairia occidentalis possesses
hypoglycemic effect in alloxan diabetic rats and could be useful in the
ethnotherapy of type 2 diabetes.]]>Aderibigbe, A.O., B.A.S. Lawal and J.O. Oluwagbemi,1991Telfaira occidentalis in mice.]]>28171175Ajayi, O.I., T.C. Ajayi, E.D. Omokaro and N.K.D. Halim,2000Telfaira occidentalis in rabbit. A preliminary study.]]>1613Akhtar, M.S., M.A. Ather and M. Yaqub,1981Mormordica charantia on blood glucose level of normal and alloxan diabetic rabbits.]]>42205212Akoroda, M.O.,1990Telfairia occidentalis (cucurbitaceae) among Igbos of Nigeria.]]>442939Anosike, E.O.,1994pp: 70-71pp: 70-71Asiegbu, I.E.,198740151155Badifu, G.I.O. and A.O. Ogunsua,1991Cucurbitaceae grown in Nigeria.]]>413544Bosa, E.O. and E.M. Mgbeogu,1983Telfaira occidentalis, West African vegetable crop.]]>37145149Eseyin, O.A., E. Oforah and B.D. Dooka,2000Telfaira occidentalis in Normoglycaemic Guinea Pigs.]]>6639641Eseyin, O.A., A.C. Igboasogiyi, E. Oforah, P. Chin and B.C. Okoli,2005T. occidentalis leaves on some Biochemical Parameters in rat.]]>118587Eseyin, O.A., A.C. Igboasoiyi, E. Oforah, N. Nkop and A. Agboke,2005Telfaira occidentalis in rats.]]>23642Lucas, E.O.,198817163163Meigs, J.B., D.C. Muller, D.M. Nathan and D.R. Blake, R. Andres, 20035214751484Nwozo, S.O., O.A. Adaramoye and E.O. Ajaiyeoba,2004Telfaira occidentalis on alloxan induced diabetic rabbits.]]>84547Odoemena, C.S.,199141107111Odoemena, C.S. and J.P. Essien,1995Telfairia occidentalis (Fluted pumpkin).]]>402932Odoemena, C.S. and E.C. Onyeneke,1998Telfaira occidentalis. First Afric.]]>1998Oluwole, F.S., A.O. Falode and O.O. Ogundipe,2003183538Sharma, M.K., A.K. Khare and H. Feroz,1983117380383