Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2007.3158.3161Artemisia herba alba Ingestion in Female Spague-dawley Rats]]>AlmasadMotasem M.QazanWalid Sh.DaradkaHaytham 1220071018The objectives of this study is to investigate the toxic effects of Artemisia herba Alba (300 mg/kg/ body wight) on the reproductive system after administration to female Sprague-Dawley rats weighting 250-300 g for two time periods 4 and 12 weeks. Twenty adult female rats were divided into two groups and exposed to Topiramate diet at a concentration of 300 mg/kg/body weight for two periods of time. First group containing 10 rats received treatment for 4 weeks and a second group of 10 rats received the same dose of treatment for a period of 12 weeks and compared with twenty non-exposed female rats received vehicle treatment. Female rats were allowed mating with males after 10 days prior to the last administration dose. Animals were autopsied under light anesthesia after mating and several parameters were determined including: Number of pregnant rats, body and reproductive organ weight, number of implantation sites, viable fetuses and resorption sites. Assessment of pregnancies in females was measured and the significance of these results was calculated using students t and Chi-square tests. The effect of Artemisia herba alba exposure on fertility was assessed in terms of pregnant rats number, implantation sites, viable fetuses and resorption sites. Exposure to Artemisia herba alba for 4 weeks did not have much effect on fertility. Significant decrease in the relative ovarian weights and embryo weights in rats exposed to Artemisia herba alba were observed. Exposure to Artemisia herba alba for a 12 weeks resulted in a reduction in the percentage of pregnancies and in the number of implantation sites when compared with controls in both treatment periods. Rats receiving 12 weeks treatment showed an increase in ovarian weights and a decrease in viable fetuss number. These results indicate that long-term exposure of female rats to Artemisia herba Alba causes adverse effects on the reproductive system and fertility. The results of the current study suggest that ingestion of Artemisia herba alba by adult female rats causes adverse effects on fertility and reproduction.]]>Agrawal, S., S. Chauhan and R. Mathur,198618125131Choudhary, A.K. and E. Steinberger,197512609617Dixon, W. and F.J. Massey,1957Pages: 228Pages: 228Foglio, M.A., P.C. Dias, M.A. Antonio, A. Possenti and R.A. Rodrigues et al.,2002A. annua.]]>68515518Haynes, R.K.,20066509537Kamboj, V.P. and B.N. Dhawan,19826191226Khafagy, S.M. S.A. Gharbo and T.M. Sarg,1971Artemisia herba alba.]]>209096Khouri, N.A. and Z. El-Akawi,2005Ruta graveolens L. in male Albino rats with emphasis on sexual and aggressive behavior.]]>26269275Kordali, S., R. Kotan, A. Mavi, A. Cakir, A. Ala and A. Yildirim,2005Artemisia dracunculus and of the antifungal and antibacterial activities of Turkish Artemisia absinthium, A. dracunculus, Artemisia santonicum and Artemisia spicigera essential oils.]]>5394529458Lane-Petter, W. and A.E.G. Pearson,1971Pages: 226Pages: 226Iriadam, M., D. Musa, H. Gumushan and F. Baba,2006Artemisia herba-alba and Teucrium polium on blood glucose levels and other biochemical parameters in rabbits.]]>51924Purohit, A. and H.M.M. Daradka,1999Curcuma longa (50% EtOH extract) with special emphasis on testicular cell population dynamics.]]>36142143Saleh, M.A., M.H. Belal and G. El-Baroty,2006Artemisia herba alba Asso (Asteraceae).]]>41237244Shapira, Z., J. Terkel, Y. Egozi, A. Nyska and J. Friedman,1989Peganum harmala.]]>27319325Stermitz, F.R., L.N. Scriven, G. Tegos and K. Lewis,2002Artemisa annua which potentiate the activity of berberine and norfloxacin against a resistant strain of Staphylococcus aureus.]]>6811401141Saadali,B., D. Boriky, M. Blaghen, M. Vanhaelen and M. Talbi,2001Artemisia dracunculus.]]>5810831086