Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2007.2073.2077Loranthus globosus Roxb]]>IslamRobiul AlamA.H.M. KhurshidRahmanB. M.SalamK. A.HossainAslam BakiAbdullahil SadikGolam 1220071012 The sub-acute toxicities of two compounds 3,4-dimethoxycinnamyl alcohol (1) and 3,4,5-trimethoxycinnamyl alcohol (2) isolated from the plant Loranthus globosus Roxb were studied on long Evan’s rats. The studies included the gross general observation such as changes in body weight, haematological profiles [total count of Red Blood Cells (RBC) and White Blood Cells (WBC), differential count of WBC, platelet count and Haemoglobin (Hb) %], biochemical parameters of blood [Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), Serum Alkaline Phosphatase (SALP), urea and creatinine) and histopathology of the liver, kidney, heart and lung of both control and experimental groups of rats. The changes in haematological and biochemical parameters were statistically not significant after the administration of compounds 1 and 2 in a dose of 300 μg/rat/day for consecutive 14 days. No abnormality was found in the histopathology of the liver, kidney, heart and lung in the experimental groups of rats following same dose when compared with control group. This preliminary study suggests that the isolated compounds may be used safely for clinical trial.]]>Amabeoku, G.J., M.J. Leng and J.A. Syce,1998Viscum capense.]]>61237241Block, E. and R. Stevenson,19713634533453Coulombe, H. and I. Favreau,19639107108Fawcett, J.K. and J.F. Scott,196016156159Fernandez, T., P.C. Zolezzi, P. Aulicino, C.E. Lopes and M. Wagner et al.,2003Ligaria cuneifolia.]]>858192Harvala, E., J. Exner and H. Becker,1984Loranthus europaeus.]]>4710541054Hasan, M.A.,1993Hawk, P.B., B.L. Oser and W.H. Summerson,195413th Edn.,pp: 573-575pp: 573-575Hooker, J.D.,1890ISI Database,20022002Islam, R., A.H.M.K. Alam, M.A. Hossain, M.A. Mosaddik and G. Sadik,200475405408King, E.J. and A.R. Armstrong,193431376381Lohezic-Le-Devehat, F., A. Bakhtiar, C. Bezivin, M. Amoros and J. Boustie,200273400405Obatomi, D.K., E.O. Bikomo and V.J. Temple,1994431317Ohashi, K., H. Winarno, M. Mukai, M. Inoue, M.S. Prana, P. Simanjuntak and H. Shibuya,2003Scurrula atropurpurea (Loranthaceae).]]>51343345Reitman, S. and S. Frankel,1957285663Sadik, G., R. Islam, M.M. Rahman, P. Khondkar, M.A. Rashid and S.D. Sarker,2003Loranthus globosus.]]>74308311Yoon, T.J., Y.C. Yoo, T.B. Kang, K. Shimazaki and S.K. Song et al.,1999Viscum album coloratum) induce apoptosis in tumor cells.]]>1363340Zarkovic, N., T. Kalisnik, I. Loncaric, S. Borovic and S. Mang et al.,1998Viscum album lectin ML-1 and fresh plant extract (Isorel) on the cell growth in vitro and tumorigenicity of melanoma B16F10.]]>13121131