Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2006.816.819AhmedRukhsana Khursheed Hashmi Saiyed Ehsan ullah Tanveer Khanum Rafia Azmat 5200695A prospective study was planned to determine the prevalence of anti-rubella antibody in female of reproductive age in Karachi to eliminate rubella virus infection to prevent CRS (Congenital Rubella Syndrome) by evaluating the importance of immunization of infants and susceptible females. About 1,225 women, referred to Dr. Ehsanullah`s Laboratory Karachi, during year 1999 to 2004 from various maternity homes for antenatal checkup, were included in this study. Rubella IgG antibodies determined by Enzyme Linked Immuno Sorbent Assay (ELISA). About 81% pregnant women were found to be seropositive by clinical or subclinical rubella infection/immunization (immune group) and 18% of pregnant women were seronegative for Rubella antibody of the I gG class with high risk of CRS (susceptible group), which can be reduced or eliminated by immunization programme for infants and adult females before marriages.]]>Anonymous,200314359363Anonymous,20055279282Cooper, L.Z., P.R. Ziring, A.B. Oskerse, B.A. Fedum, B. Kiely and S. Krugman,199696247253Mata, De la I. and P. De Wals,19884175180Miller, E., J.E. Cradock-Watson and T.M. Pollock,19822781784Peckham, C.S.,197247571577Peckham, C.S.J., A.M. Martian, W.C. Marshall and J.A. Ydgeib,19791258261Robertson, S.E., F.T. Cutts, R. Samuel and J.L. Diaz-Ortega,1997756980Tariq, W.Z., Ziaullah and K.A. Karamat,2002529295Advisory Committee on Immunization Practices, Centers for Disease Control and Prevention,20015011171117Anonymous,199039RR-15RR-15Anonymous,20052005Anonymous,200554175175CDC,19951995Committee on Infectious Diseases, American Academy of Pediatrics,199423rd Edn.,pp: 406-412pp: 406-412Cooper, Z.L.,19901990pp: 723-725pp: 723-725Cooper, L.Z. and C.A. Alford,20012001pp: 347-388pp: 347-388