Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2006.1536.1541ShekharHossain UddinShahjalalHussain Md.AhmedRumana UddinMesbah Kaniz-Khatun-E-Jannath 8200698Diabetic patients are vulnerable to different lethal diseases including cardiovascular disease, which is still ranked as the number one killer disease in the world. In the present study, the vulnerability of diabetic patients to cardiovascular disease was evaluated considering apoB level as a predictor. Randomly selected Bangladeshi 96 type 2 diabetic patients (M = 48, F = 48) and 49 healthy non-diabetic individuals (M = 37, F = 12) were recruited to compare their anthropometric and biochemical features. Among the diabetic subjects 32 were hypercholesterolemic (LDL-C>150 mg dL-1) and 64 were normocholesterolemic (LDL-C<150 mg dL-1). The biochemical parameters compared were total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C) and apolipoprotein B (apoB). The values for the diabetic patients vs. control were: TC, 214±46 vs. 186±18 mg dL-1; LDL-C, 143±40 vs. 120±18 mg dL-1; TG, 192±79 vs.141±33 mg dL-1 and HDL-C, 35±6 vs. 39±7 mg dL-1; with all p value<0.05. The values for the normocholesterolemic diabetic patients vs. control were: TC, 189±28 vs.186±18 mg dL-1; LDL-C, 120±23 vs. 120±18 mg dL-1; TG, 184±84 vs. 141±33 mg dL-1 and HDL-C, 35±7 vs. 39±7 mg dL-1; of which values of TG and HDL-C were significant. Serum apoB level for the diabetic patients vs. control was 1.15±0.28 vs. 0.926±0.25 g L-1 (p<0.05) and the normocholesterolemic diabetic patients vs. control was 1.06±0.26 vs. 0.926±0.25 g L-1 (p<0.05). 47% (n = 30) of the normocholesterolemic diabetic patients had hyper-apoB, of which 22% were hypertriglyceridemic and 25% were normotriglyceridemic. Surprisingly, hyper-apoB was also found in 14% of control. Thus apoB identified the high-risk phenotypes in normocholesterolemic diabetic patients and it should be used to evaluate the lipidic pattern of these patients.]]>Assmann, G. and H. Schulte,198811617131724Austin, M.A.,19998313F16FBrown, M.S. and J.L. Goldstein,19862323447Contois, J.H., J.R. McNamara, C.J. Lammi-Keefe, P.W. Wilson, T. Massov and E.J. Schaefer,199642515523Cummings, M.H., G.F. Watts, A.M. Umpleby, T.R. Hennessy and R. Naoumova et al.,199538959967Elovson, J., J.E. Chatterton, G.T. Bell, V.N. Schumaker and M.A. Reuben et al.,19882914611473Gotto, A.M.,19989710271028Haffner, S.M.,199821160178Isomaa, B., P. Almgren, T. Tuomi, B. Forsen and K. Lahti et al.,200124683689Kannel, W.B.,198511011001107Kwiterovich, P.O., J. Coresh and P.S. Bachorik,199371631639Lamarche, B., J.P. Despres, S. Moorjani, B. Cantin, G.R. Dagenais and P.J. Lupien,19957511891195Lamarche, B., S. Moorjani, P.J. Lupien, B. Cantin, P.M. Bernard, G.R. Dagenais and J.P. Despres,199694273278Lamarche, B., A. Tchernof, S. Moorjani, B. Cantin, G.R. Dagenais P.J. Lupien and J.P. Despres,1997956975Malmstrom, R., C.J. Packard, M. Caslake, D. Bedford and P. Stewart et al.,199740454462NCEP.,199326930153023Phillips, N.R., D. Waters and R.J. Havel,19938827622770Sniderman, A.D., C. Wolfson, B. Teng, F.A. Franklin, P.S. Bachorik and P.O. Kwiterovich,198297833839Sniderman, A.D., T. Scantlebury and K. Cianflone,2001135447459Stamler, J., O. Vaccaro, J.D. Neaton and D. Wentworth,199316434444Syvanne, M. and M.R. Taskinen,19973502023Taskinen, M.R.,19904743775Westerveld, H.T., J.E. Van Lennep, H.W. Van Lennep, A.H. Liem and J.A. De Boo et al.,19981811011107Whitney, E.N. and E.M. Hamilton,19874th Edn.,pp: 248pp: 248Young, S.G.,19908215741594