Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2004.73.78RafiqK. MostofaM. SaifulM. 1200471The objectives of this studies was to select an ideal anthelmintic which was incorporated in blocks, to know the efficacy of medicated urea molasses mineral block (MUMMB) against gastrointestinal nematode parasites in naturally infested indigenous dairy cows and its cost benefit analysis. To fulfill these objectives naturally infested 72 indigenous dairy cows with gastrointestinal nematode parasites were selected for this study. The cows were offered normal diet added with 250 gm differents block/ cow/ day. Comparative stability trials were carried out with three anthelmintic (albendazole, fenbendazole and thiophanate) on 48 dairy cows. After comparative anthelmintic efficacy trails all three anthelmintic separately mixed with molasses-mixture and kept in laboratory under normal environmental conditions up to 4 months. After 4 months comparative efficacy trails of those anthelmintic incorporated in molasses mixture were done against naturally infested gastrointestinal nematodes parasites in dairy cows. Efficacy of medicated blocks against gastrointestinal nematodiasis was evaluated by examining faecal EPG reduction throughout the licking period, which was compared with pre-treatment EPG value. In this study three types of blocks such as medicated urea-molasses-mineral block(MUMMBa, 0.3gm fenbendazole/kg block), medicated-urea-molasses-mineral blocks (MUMMBb, 0.4gm fenbendazole/kg block) and urea-molasses blocks(UMMB) were prepared. cost benefit analysis of the medicated blocks licks was calculated based on the present cost of ratio components and milk sale value. Fenbendazole was found to be stable in blocks and was selected for the preparation of medicated blocks. Medicated blocks MUMMBa offered to lick by naturally infested dairy cows with gastrointestinal nematode parasites showed EPG reduction from 976.26±98.04 to 70.88±20.99 and when medicated blocks MUMMBb, offered to lick by naturally infested dairy cows with gastrointestinal nematodes parasites, showed EPG reduction from 958.33±102.06 to zero within seven days. The same result still remained during the experiment. Whereas UMMB also reduced EPG about 13.44%. The cost benefit analysis showed that marginally there was increase in the feed cost in medicated block licks group but it was profitable under consideration to milk sale. Prolonged low level administration of fenbendazole through medicated-urea-molasses-mineral blocks were found to have therapeutic and prophylactic effect against naturally infested gastrointestinal nematode parasites of dairy cows. Use of MUMMB instead of UMMB was proved to be better for parasites of dairy cows under the village condition of Bangladesh where balanced ration for dairy cows also was a major scarcity and was found to be cost effective.]]>Anderson, N., R.H. Laby, R.K. Prichard and D.R. Hennessy,198029333341Bauer, C., H. Holtemoller and K. Schmid,1997140395399Karim, R., K. Rafiq, M. Mostofa and Q. Hasan,1998327173Knox, M.R.,19961996pp: 141-149pp: 141-149Ratnaparki, M.R., U.V. Shastri, B.W. Narlandkar, S.U. Digraskar and N.M. Degloorkar,1992122020Pandit, K.K.,1981R) against gastrointestinal nematodes.]]>155760Prichard, R.K., D.R. Hennessy and J.W. Steel,19784309315Sanyal, P.K. and D.K. Singh,199317137142Sanyal, P.K. and D.K. Singh,199377181Sanyal, P.K.,1995.1995.pp: 814Charles, H. and L. Edward,19951995pp: 894-898pp: 894-898Faiz, M.A.,19721972Mazed, M.A.,19971997Rahman, M.H.,19981998Rahman, M.H., S. Ahmed and M.M.H. Mondal,19961st Edn.,pp: 17-18pp: 17-18Steel, R.G.D. and J.H. Torrie,1980