Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2003.1593.1596Annona squmosa Linn. on Long Evans Rats]]>ParvinMst. ShahnajIslamM. EkramulRahmanMd. MotiurHaqueMd. Ekramul122003618The potential toxicity of annotemoyin-1 isolated from the seeds of Annona squamosa Linn., collected from the relevant areas of Bangladesh was evaluated on Long Evan`s rats. Annotemoyin-1 (100 μgm and 200 μgm) was administered daily for 14 days and the effects on body weight, hematological and biochemical parameters of the blood and histopathological parameters of heart, kidney, lungs and liver were studied. There was no significant difference between weight gain in rats receiving annotemoyin-1 and control rats. The changes of hematological and biochemical parameters were statistically insignificant. No abnormalities were found in the histopathological parameters of heart, kidney, lungs and liver of the experimental groups of rats when compared with control groups of rats. From this study, it was inferred that annotemoyin-1 (100 μgm and 200 μgm) over 14 days, had no toxic effect on rats.]]>Hawk, P.B., L. Oser and W.H. Summerson,199313th Edn.,Parvin, M.S.,2002Annona squamosa Linn.]]>2002Reitman S. and S. Frankel,1957285657Ghani, A.,19981st Edn.,pp: 1-7pp: 1-7Coulomb, J.J. and L. Favreau,19639102108Fawcett, J.K. and J.E. Scott,19609156169Kirtikar, K.R. and B.D. Basu,19932nd Edn.,pp: 715-716pp: 715-716King, P.J. and A.R. Armstrong,193431376381Prain, D.,19632nd Edn.,pp: 128-134pp: 128-134Duret, P., A.I. Waechter, R. Hocquemiller, A. Cave and D. Batten,1996Annona atemoya.]]>88996