Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2003.1413.1415SiddiquiBazghah SadafBhattiHaq NawazIjazAmbreen RasheedSaba SaleemBushra 122003616Acetylsalicylic acid is a non-steroidal anti-inflammatory drug. Urinary excretion of ASA (as free
salicylic acid) was investigated in twelve healthy male volunteers after an oral administration of 600
mg dose. Urine samples were collected upto 10 h. The concentration of drug was determined
colorimetrically and mean ±SE value in urine was found to be 37.55±0.418 μg mL1. The values for
diuresis and rate of excretion was 0.028±0.006 mL min1 kg1 and 0.849±0.226 μg min1 kg1. The
amount of free SA excreted was 5.40±1.15 mg. The % dose excreted was 0.92±0.19%. Cumulative
amount and % cumulative dose excreted was found to be 17.74±2.91 mg and 5.47±0.78%. There is
slight variations in urinary excretion data when compared with foreign investigated values.]]>Amick, E.N. and W.D. Mason,197912629640Farid, N.A., G.S. Born, W.V. Kessler, S.M. Shaw and W.E. Lange,19752111671168Fatima, K.,20022002Hartwig-Otto, H.,1983753037Hutt, A.J., J. Caldwell and R.L. Smith,198616239249Levy, G. and T. Tsuchiya,1972287430432Levy, G.,196354959967Low, L.K.,199810th Edn.,pp: 110-111pp: 110-111Mays, D.C., D.E. Sharp, C.A. Beach, R.A. Kershaw, J.R. Bianchine and N. Gerber,1984311101309Nawaz, M.,199472307307Reynolds, J.E., F.K. Parfitt, A.U. Parson and S.C. Sweetman,1989pp: 32pp: 32Steel, R. and J.H. Torrie,1992Wesley, G.C., D.Q. Craig, M.D. Brater and A.R. Johnson,1990Asian Student Edn.,Simon, L.S. and J.A. Mills,198030211791185