Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2002.1220.1225Wafaa B. Yousif 112002511Effects of the administration of Alprazolam (Xanax) were studied on the liver of the mice. Animals were treated orally with different daily doses of 0.01, 0.1 and 0.2 mg of alprazolam/kg body wt. for 21 days. In the animals treated with the two high therapeutic doses (0.1 and 0.2 mg), light microscopic examination showed enlargement of the nuclei, vacuolation of the cytoplasm, proliferation (hyperplasia) and hypertrophied of Kupffer cells. Extensive morphological changes in the liver cells were revealed by electron microscope including decrease in heterochromatin, extensive enlargement and fragmentation of the nucleoli, decrease of mitochondria, rough endoplasmic reticulum and glycogen contents, hypertrophied golgi apparatus, increase and dilation of smooth endoplasmic reticulum, increase of lipid droplets, vacuolation of cytoplasm.]]>Anonymous, 1990Aparasu, R.R., J.R. Mort and S. Salzman, 199820603616Biava, C. and M. Montiel, 196546775787Cantor, E.H., A. Kennessy, G. Senemuk and S. Spector, 19848115491552Cardell, R.R., 19711312154Chevemont, M., S. Chevermont-Comhaire and H. Firket, 1956in vitro et en particulier de ses effets sur la mitose. ]]>67635656Chipchase, M.I. and M. Birnstiel, 19635011011107Ferguson-Chanowitz, K.M., A.S. Katocs and W.C. Pickett, 199016210811086Freeman, E.W., K. Rickets, S.J. Sondheimer and M. Polansky, 19952741557Glaser, G. and J. Magner, 1972261500507Graham, C.W., R.R. Pagano and R.L. Katz, 197756409413Greenblatt, D.J., L. von Moltke and J.S. Harmatz, 1998591927Gustafsson, R.G. and B.A. Afzelius, 19633010451075Harrison, W.M., J. Endicott and J. Nee, 199047270275Harro, J., E. Vasar and J. Brasdwejn, 199314244249Hewers, 19732nd Edn.,Hjalmarson, A.C., D.E. Rannels, R. Kao and H.E. Morgan, 197525045564561Junqueira, L.C., J. Carneiro and R.O. Kelley,19958th Edn.,Karasaki, S., 196526937958Klatskin, G., 196141443451Knil, R.L. and D. Evans,197522637646Labib, M.M., A.M. Kandil and H.D. Saleh, 200035413430Levine, L., 198843793799Lichtman, A.H., G.B. Segel and M.A. Lichtman, 198361413422Lucki, I., K. Rickels and A.M. Geller, 198688426433Massoud, A.A., G.A. Madkour, S.A. Abdel Baset and M. Hassan, 19916199210Merski, J.A., Y. Daskal and H. Busch, 19763615801584Moris, G.A.,19916229244Moustafa, N., M. Omran, W. Abdel-hafez, M. Kotb, Z. Kamel and H. Khalil, 19836259267Paroli, E. and S. Caprino, 19592186187Pisciotta, A.V. and J. Kaldahl, 1962in vitro.]]>29364376Pawlikowaski, M., H. Stepien, Z. Morz-Wasilewska and A. Pawlikoski,19874011311135Pawlikowski, M., J. Kurnet-Radek, A. Redak and H. Stepien,1988in vitro.]]>77231233Ramadan, A.A., W.B. Yousif, J. Souror and S. Zaki, 199713199210Ruebner, B. and K. Miyai, 196240425435Salzman, C.,19974279282Salzman, C., 199869251261Salzman, C., 199928111211125Salzman, C. and J.I. Sheikh,19981998pp: 333-341pp: 333-341Schoefl, G.I., 196410224243Shader, R. and D.J. Greenblatt, 199332813981405Snell, R.S.,1984pp: 477-502pp: 477-502Stenghever, M.A., R.S. Frankel and J.A. Jarvis,1970in vivo.]]>107456460Trevor, A.J. and W.T. Way,19981998Tupikava, Z.N.,1957222286307Yousif, W.B. and M.M. El-Rawi,20003595109