Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2000.555.557In vivo Effects of Ibuprofen and Naproxen on the Plasma Concentration of Diltiazem in Rabbits]]>BariA.H.M. Rashidul A.T.M. Zafrul Azam Md. Shah Amran Md. Amjad Hossain 4200034An in vivo study has been carried out to evaluate the influence interaction of ibuprofen and naproxen on the plasma concentration of diltiazem in rabbits. The study has bee carried out by UV Spectrophotometric method. It has been found that the concurrent administration of diltiazem and ibuprofen has no effect on plasma concentration of diltiazem in rabbits. But concurrent administration of diltiazem and naproxen causes a significant decrease in plasma concentration of diltiazem. These results indicate that great care and monitoring is to be practiced during concurrent administration of diltiazem with naproxen to avoid untoward pharmacological and therapeutic actions related to drug-drug interactions.]]>Bauer, L.A., M. Stenwall, J.R. Horn, R. Davis, K. Opheim and L. Greene,198640239242Carlsted, B.C. and W.F. Stanazek,1990Angina pectoris.]]>106274Choi, J.S. and I. Chang,1993232741Dargie, H.J., P.G. Lynch, D.M. Krikler, L. Harris and S. Krikler,198171676682Gilman, A.G., L.S. Goodman, R.W. Rail and F. Murad,19818th Edn., Vol. 1, 2,pp: 1-2, 12, 395, 774-780, 927, 1292-1293, 168012pp: 1-2, 12, 395, 774-780, 927, 1292-1293, 168012Hamann, S.R., K.E. Kaltenborn and R.G. McAllister, Jr.,198710182189Kohno, K., Y. Takeuchi, A. Etoh and K. Noda,19772714241428Lever, A.M., P.A. Corris and G.J. Gibson,198439576578Martin, K.,1987199783791Martindale, W.,199330th Edn.,pp: 374-380, 621-623, 884-885, 1038-39pp: 374-380, 621-623, 884-885, 1038-39Rahatuzzaman, M., M.S. Amran and M.A. Hossain,1999In vivo study of effect of nifedipine, ketotifen fumarate and potassium nitrate on plasma concentration of diltiazem in rabbit.]]>165761Gennaro, A.R.,199018th Edn.,pp: 721-723, 750, 853-855, 1116, 1118pp: 721-723, 750, 853-855, 1116, 1118Van Lith, R.M. and D.H. Appleby,198519829831