Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.1999.1155.1158Helicobacter Pylori- Associated-Gastric Epithelial Cells and Predicting Tumorgenesis]]>AbdelmeguidN. E. 4199924Helicobacter pylori infection appears to be the most important cause of gastritis, gastric and duodenal ulcer. Biopsy specimens of gastric mucosa of patients with chronic gastritis proven by bacteriological test and endoscopy assessed the presence of organisms in lumen of numerous glands. Light and electron micrographs revealed curved organism, quite close to superficially damaged epithelial cells. Although no direct contact could be detected between the organisms and the epithelial cells yet they influenced their outlook. Changes on the microvillus surface, as well as within the epithelial cells were noticed. The most important of which are the frequent presence of pale- nuclei, type 1 nuclear pocket and nuclear inclusion in the nuclei and pusity of organelle in their cytoplasm. The observation indicated disturbed metabolism and predicting early transformation of normal cells to tumor cells.]]>Abdelmeguid, N.E., M.M. El-Mofty, I.A. Sadek, A.E. Essawy and E.A. Abdel-Aleem,199754258263Bartel, H., S. Orkisz, J. Chojnacki and A. Kulig,1992431618Chlumska, A. and M. Sedlackova,1995Helicobacter pylori-positive gastritis.]]>31119121Freedberg, A.S. and L.E. Barron,19407443445Gasbarrini, A, F. Franceschi, G. Gasbarrini and P. Pola,19979231233Ghadially, F.N.,19852nd Edn.,Guisset, M., T. Coton, P. Rey and J.M. Debonne,1997Helicobacter pylori infection in developing countries.]]>577782, (In French)Janas, B., E. Czkwianianc, L. Bak-Romaniszyn, H. Bartel, D. Tosik and I. Planeta-Malecka,1995Helicobacter pylori and gastric epithelial cells.]]>9018291833Kobayashi, H., Y. Kajitani, T. Maekawa, T. Itoh and R. Murata et al.,199549195200Marshall, B.J. and I. Surveyor,1988291116Noach, L.A., T.M. Rolf and G.N. Tytgat,1994Helicobacter pylori and gastric and duodenal mucosa.]]>47699704Taniguchi, Y., K. Kimura, K. Satoh, Y. Yoshida and K. Kihira et al.,1995Helicobacter pylori detected deep in gastric glands: An ultrastructural quantitative study.]]>21S169S173Tursi, A., G. Cammarota, A. Papa, L. Cuoco and N. Gentiloni et al.,1997Helicobacter pylori infection.]]>88232236Senoo, A., Y. Fuse and F.N. Ghadially,198416379386Zaitseva, K.K.,1991Helicobacter pylori in patho- and morphogenesis of chronic gastritis and peptic ulcer.]]>537275