Pharmacologia2044-46482044-4656Science International10.3923/pharmacologia.2017.18.24Cochlospermum planchonii in Albino Rats]]>Abraham BamisayeFisayo SulymanAbdulhakeem Olarewaju Oladipo AjaniEmmanuel Aduke AlabiVictoria 1201781Background and Objective: Cochlospermum planchonii is used for various purposes such as food additive, dye, rope making and medicine for treatment of various ailments in Nigeria. The plant is consumed indiscriminately by users. This study aims to evaluate toxicological effects of aqueous leaves extract of Cochlospermum planchonii (C. planchonii) in albino rats. Materials and Methods: The qualitative phytochemical screening of aqueous leaves extract of C. planchonii was carried out to ascertain the bioactives present in the extract. Albino rats weighing between 200 and 224 g were grouped into four (A-D) consisting of ten rats each. Group A (control) orally received 1 mL of distilled water while groups B-D received 50, 100 and 200 mg kg1 b.wt., of the extract, respectively for 28 days. At the end of the experiment, these experimental rats were sacrificed and their blood, liver and kidney were collected for toxicological studies. In addition, histopathological studies of liver and kidney of the rats were also carried out. Statistical analysis was done by one-way analysis of variance (ANOVA) and Duncan multiple range test. Results: The aqueous leaves extract of C. planchonii contain alkaloids, cardenolides, cardiac glycosides, flavonoids, phenolics, saponnins, terpenoids and tannins while antraquinones and steroids were not detected. The extract supports growth in a dose dependent manner with best growth shown in rats treated with the highest concentration (200 mg kg1 b.wt.). In addition, the extract reduced the electrolyte concentrations while it increased bilirubin and blood creatinine concentrations in rats. Furthermore, histopathological studies of the liver and kidney of extract-treated rats revealed dissociation of hepatic cords in the hepatic parenchyma of the liver while few foci of nephrosis (coagulative tubular necrosis) were seen in their kidney at the end of the experiment. Conclusion: Aqueous leaves extract of C. planchonii may not be safe when consumed for long period of time, especially at high concentrations.]]>Mikhail, O. and M.A. Akanji,2013Cochlospermum planchonii (Hook. Ef. x Planch) root.]]>2013Petrovska, B.B.,2012615Ngarivhume, T., C.I.E.A. van't Klooster, J.T.V.M. de Jong and J.H. Van der Westhuizen,2015159224237Oyen, L.P.A.,2010Cochlespermum planchonii (internet)prota 16; fibres/plantes a fibres record display prota.]]>2010Lim, T.K.,2013Pages: 1102Pages: 1102Paul, O.N., G.S. John, A. Ukpe, O.A. Ijeoma, C.U. Chinedu and T.P. Yakubu,2011Cochlospermum planchonii, Hoof F (Euphorbiaceae).]]>3209218Adewale, O. and A.Y. Faremi,2010pp: 54-73pp: 54-73NRC.,1985Pages: 83Pages: 83Plummer, D.T.,19782nd Edn.,pp: 144-147pp: 144-147Vijay, K., M.S. Brody, E. Fredlund and C.W. Price,2000B transcription factor of Bacillus subtilis.]]>35180188Duncan, D.B.,195713164176Bhragual, D.D., N. Kumar, V.K. Garg and P.K. Sharma,2010320772082Priya, V.V., S. Niveda, G. Pratiksha and R. Gayathri,201024952Deshwal, N., A.K. Sharma and P. Sharma,201171526Singh, A., T.K. Bhat and O.P. Sharma,20112011McPherson, R.A.,20112011pp: 259-272pp: 259-272Jaganmohan, S. and J.H. Lee,20126105114Sangu, P.K., V.M. Kumar, M.S. Shekhar, M.K. Chagam, P.P. Goli and P.K. Tirupati,2011Tailabindu pariksha-An ancient Ayurvedic method of urine examination as a diagnostic and prognostic tool.]]>327681Gowda, S., P.B. Desai, S.S. Kulkarni, V.V. Hull, A.A.K. Math and S.N. Vernekar,20102170173Allen, P.J.,20123614421462Samra, M. and A.C. Abcar,2012165152Dorgalaleh, A., M. Mahmudi, S. Tabibian, Z.K. Khatib and G.H. Tamaddon et al.,201373439Park, J.,20122012Shahjahan, J. Subzwari, M.A.J. Mahsood, F. Majid, F. Aslam and Aziz Ur Rehman,2012107679Idonije, B.O., O. Festus and O.M. Oluba,2011513Liamis, G., E. Liberopoulos, F. Barkas and M. Elisaf,20142488496Syzdek, J., M. Armand, M. Marcinek, A. Zalewska, G. Zukowska and W. Wieczorek,20105513141322Perzyna, K., R. Borkowska, J. Syzdek, A. Zalewska and W. Wieczorek,2011575865Lee, J.W.,201087281Liamis, G., E.M. Rodenburg, A. Hofman, R. Zietse, B.H. Stricker and E.J. Hoorn,2013126256263Liamis, G., H.J. Milionis and M. Elisaf,201163327335