Pharmacologia2044-46482044-4656Science International10.3923/pharmacologia.2016.150.156VeereshB. AlviSyed Baseeruddin ArchanaK. 2-3201672-3Background: Colon cancer is considered as the third most common cancer affecting both developed and developing countries. In the current study, n-butylidenephthalide (BP) a compound extracted from traditional Chinese herb Radix Angelica sinensi was assessed against 1,2-dimethylhydrazine (DMH)-induced colon cancer. Materials and Methods: To promote colon cancer, DMH (20 mg kg1, s.c.) was administered twice a week for two weeks. To evaluate the protective effect of BP, it was co-administered with DMH in 150 and 300 mg kg1 (p.o.) to respective groups for a total period of seven weeks. At the end of treatment, colon tissue was excised for various biochemical and microscopic evaluation. Results: Administration of BP 150 and 300 mg kg1 to respective groups revealed significant alteration in various biochemical parameters like MDA, GSH, SOD and catalase (p<0.05 and p<0.01), respectively. Microscopic studies conducted on colonic tissue revealed reduced crypt multiplicity following treatment with BP 300 mg kg1. Furthermore, histopathological and transmission electron microscopic studies showed remarkable reduction in dysplasia, normal cellular and sub cellular structures, respectively. Conclusion: In the present study, significant results were produced with the treatment of BP in graded manner and exhibited protective effect against DMH induced colon cancer in mice by virtue of its antioxidant and antitumor activity.]]>Sirohi, B., S.V. Shrikhande, B. Perakath, D. Raghunandharao and P.K. Julka et al.,201435192196American Cancer Society,20142014Chan, D.S., R. Lau, D. Aune, R. Vieira, D.C. Greenwood, E. Kampman and T. Norat,20112011Noda, N. and H. Wakasugi,200144535539Wang, J.G., D.F. Wang, B.J. Lv and J.M. Si,20041029582962Aranganathan, S. and N. Nalini,20094725942600Jia, X.D. and C. Han,20006699703Bird, R.P.,198737147151Wu, Y.C. and C.L. Hsieh,2011Angelica sinensis (Danggui) on cerebral infarction.]]>2011Chiu, S.C., S.P. Chen, S.Y. Huang, M.J. Wang, S.Z. Lin, H.J. Harn and C.Y. Pang,20122012Chen, Y.L., M.H. Jian, C.C. Lin, J.C. Kang and S.P. Chen et al.,2008n-butylenephthalide as pharmaceuticals on hepatocellular carcinoma cell therapy.]]>7410461058Wei, C.W., C.C. Lin, Y.L. Yu, C.Y. Lin and P.C. Lin et al.,20093012971306Xiao, H., X. Hao, B. Simi, J. Ju, H. Jiang, B.S. Reddy and C.S. Yang,200829113119Ohkawa, H., N. Ohishi and K. Yagi,197995351358Misra, H.P. and I. Fridovich,197224731703175Aebi, H.,1984in vitro.]]>1984pp: 121-126pp: 121-126Ellman, G.L.,1959827077Tsikas, D., 20078515170Yee, Y.K., V.P.Y. Tan, P. Chan, I.F.N. Hung, R. Pang and B.C.Y. Wong,20092418101816Moghimi-Dehkordi, B. and A. Safaee,201247175Chiu, B.C.H., B.T. Ji, Q. Dai, G. Gridley and J.K. McLaughlin et al.,200312201208Perse, M. and A. Cerar,2005396170Mahmood, N.A.,2010316Erata, G.O., O. Kanbagli, O. Durlanık, T. Bulut, G. Toker and M. Uysal,2005357478Tsai, N.M., Y.L. Chen, C.C. Lee, P.C. Lin and Y.L. Cheng et al.,2006Angelica sinensis inhibits malignant brain tumor growth in vitro and in vivo.]]>9912511262